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Tbio
LRRTM2
Leucine-rich repeat transmembrane neuronal protein 2

Protein Summary
Description
Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274711
  • ENSP00000274711
  • ENSG00000146006

Symbol
  • KIAA0416
  • LRRN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.77
gene perturbation
0.67
cell line
0.65
cell type or tissue
0.61
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (46)
1 – 10 of 46
TMEM38B
Tbio
Family: IC
Novelty: 0.03770587
p_int: 0.999458537
p_ni: 0.000541462
p_wrong: 1e-9
Score: 0.527
Data Source: BioPlex,STRINGDB
CNPY3
Tdark
Novelty: 0.24344641
p_int: 0.995410001
p_ni: 0.004589999
Score: 0.184
Data Source: BioPlex,STRINGDB
CNPY4
Tdark
Novelty: 0.34876479
p_int: 0.993564601
p_ni: 0.000172556
p_wrong: 0.006262843
Score: 0.221
Data Source: BioPlex,STRINGDB
GPC3
Tbio
Novelty: 0.00107694
p_int: 0.991983961
p_ni: 0.008015974
p_wrong: 6.5e-8
Score: 0.278
Data Source: BioPlex,STRINGDB
PTPRD
Tbio
Family: Enzyme
Novelty: 0.00348082
p_int: 0.888094379
p_ni: 0.111291159
p_wrong: 0.000614461
Score: 0.3
Data Source: BioPlex,STRINGDB
DAD1
Tbio
Family: Enzyme
Novelty: 0.00253588
p_int: 0.809042168
p_ni: 0.190741701
p_wrong: 0.000216131
Score: 0.199
Data Source: BioPlex,STRINGDB
LGR4
Tbio
Family: GPCR
Novelty: 0.01548681
p_int: 0.774336333
p_ni: 0.225165827
p_wrong: 0.00049784
Score: 0.186
Data Source: BioPlex,STRINGDB
NRXN1
Tbio
Novelty: 0.00863427
Score: 0.985
Data Source: STRINGDB
NRXN1
Tbio
Novelty: 0.00863427
Score: 0.985
Data Source: STRINGDB
NRXN3
Tbio
Novelty: 0.01732789
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.59

PubMed score by year
PubTator Score  4.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer