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Tdark
ZBTB43
Zinc finger and BTB domain-containing protein 43

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373457
  • ENSP00000362556
  • ENSG00000169155
  • ENST00000373464
  • ENSP00000362563
  • ENST00000449886
  • ENSP00000390344

Symbol
  • KIAA0414
  • ZBTB22B
  • ZNF297B
  • ZNF-X
  • ZBTB22B
  • ZNF297B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
protein domain
0.85
tissue sample
0.76
histone modification site profile
0.68
transcription factor binding site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.65   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.65   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
1
2
31.4
alcohol use disorder measurement
1
1
1
17.8
mathematical ability
2
1
2
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
31.4
alcohol use disorder measurement
1
17.8
mathematical ability
2
4.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger and BTB domain containing 43
701797
Mouse
MGI:1919084
71834
Rat
RGD:1310287
311872
Dog
zinc finger and BTB domain containing 43 [Source:HGNC Symbol;Acc:HGNC:17908]
Horse
zinc finger and BTB domain containing 43
VGNC:25150
100067188
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger and BTB domain containing 43
Mouse
Rat
Dog
zinc finger and BTB domain containing 43 [Source:HGNC Symbol;Acc:HGNC:17908]
Horse
zinc finger and BTB domain containing 43
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43298-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (28)
1 – 10 of 28
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.999999996
p_ni:  3e-9
Data Source:  BioPlex
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.99999985
p_ni:  1.04e-7
p_wrong:  4.6e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999970633
p_ni:  0.000029346
p_wrong:  2.2e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
p_int:  0.999937654
p_ni:  0.000048507
p_wrong:  0.000013839
Score:  0.519
Data Source:  BioPlex,STRINGDB
CCNL2
Tbio
Novelty:  0.03667817
p_int:  0.987903341
p_ni:  0.000042362
p_wrong:  0.012054297
Score:  0.212
Data Source:  BioPlex,STRINGDB
MSLN
Tbio
Novelty:  0.00191245
Score:  0.813
Data Source:  STRINGDB
MVB12B
Tbio
Novelty:  0.15964868
Score:  0.809
Data Source:  STRINGDB
BDP1
Tbio
Novelty:  0.00497963
Score:  0.664
Data Source:  STRINGDB
EZH1
Tchem
Family:  Epigenetic
Novelty:  0.02636757
Score:  0.644
Data Source:  STRINGDB
ITIH1
Tbio
Novelty:  0.03117546
Score:  0.61
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.65

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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