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Tbio
SRGAP3
SLIT-ROBO Rho GTPase-activating protein 3

Protein Summary
Description
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360413
  • ENSP00000353587
  • ENSG00000196220
  • ENST00000383836
  • ENSP00000373347

Symbol
  • ARHGAP14
  • KIAA0411
  • KIAA1156
  • MEGAP
  • SRGAP2
  • WRP
  • MEGAP
  • SRGAP2
  • ARHGAP14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.75
trait
0.75
histone modification site profile
0.74
microRNA
0.71
transcription factor binding site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.31   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.31   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
71.1
mathematical ability
2
2
2
64.9
waist-hip ratio
1
1
1
61.2
body fat percentage
1
1
1
29.5
sleep duration
1
1
1
25.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
71.1
mathematical ability
2
64.9
waist-hip ratio
1
61.2
body fat percentage
1
29.5
sleep duration
1
25.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SLIT-ROBO Rho GTPase activating protein 3
VGNC:8846
738969
Macaque
SLIT-ROBO Rho GTPase activating protein 3
701809
Mouse
MGI:2152938
259302
Rat
RGD:1563152
500287
Dog
SLIT-ROBO Rho GTPase activating protein 3
VGNC:46802
610229
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SLIT-ROBO Rho GTPase activating protein 3
Macaque
SLIT-ROBO Rho GTPase activating protein 3
Mouse
Rat
Dog
SLIT-ROBO Rho GTPase activating protein 3
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Inactivation of CDC42 and RAC1
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Inactivation of CDC42 and RAC1
Rho GTPase cycle
Signal Transduction
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (93)
1 – 10 of 93
SRGAP2
Tbio
Family: Enzyme
Novelty: 0.02951755
p_int: 0.99998912
p_ni: 0.000010231
p_wrong: 6.49e-7
Score: 0.95
Data Source: BioPlex,STRINGDB
PGGT1B
Tchem
Family: Enzyme
Novelty: 0.08041103
p_int: 0.999975827
p_ni: 0.000024115
p_wrong: 5.9e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
CCDC85C
Tdark
Novelty: 0.30053883
p_int: 0.999943269
p_ni: 0.000056731
Score: 0.199
Data Source: BioPlex,STRINGDB
PPP1R13B
Tbio
Novelty: 0.03903985
p_int: 0.999847264
p_ni: 0.000152736
Score: 0.267
Data Source: BioPlex,STRINGDB
CLOCK
Tbio
Family: TF; Epigenetic
Novelty: 0.00159625
p_int: 0.999531401
p_ni: 0.000434
p_wrong: 0.0000346
Score: 0.282
Data Source: BioPlex,STRINGDB
TP53BP2
Tbio
Novelty: 0.01058379
p_int: 0.934216406
p_ni: 0.065782368
p_wrong: 0.000001226
Score: 0.213
Data Source: BioPlex,STRINGDB
ACAD8
Tbio
Family: Enzyme
Novelty: 0.05735881
p_int: 0.899120832
p_ni: 0.100879168
Score: 0.243
Data Source: BioPlex,STRINGDB
SPAG5
Tbio
Novelty: 0.02392116
p_int: 0.886235384
p_ni: 0.113764614
p_wrong: 3e-9
Score: 0.303
Data Source: BioPlex,STRINGDB
ROBO1
Tbio
Novelty: 0.00494884
Score: 0.966
Data Source: Reactome,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.96
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  55.31

PubMed score by year
PubTator Score  21.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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