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Tbio
TGFB1I1
Transforming growth factor beta-1-induced transcript 1 protein

Protein Summary
Description
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361773
  • ENSP00000355117
  • ENSG00000140682
  • ENST00000394858
  • ENSP00000378327
  • ENST00000394863
  • ENSP00000378332
  • ENST00000567607
  • ENSP00000457586

Symbol
  • ARA55
  • HIC5
  • ARA55
  • HIC-5
  • TSC-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
biological process
0.92
PubMedID
0.84
gene perturbation
0.76
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.83   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.83   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (113)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Angiogenesis
PathwayCommons: panther
VEGF signaling pathway
PathwayCommons: pid
Coregulation of Androgen receptor activity
PathwayCommons: netpath
AndrogenReceptor
Name
Explore in Pharos
Explore in Source
Angiogenesis
VEGF signaling pathway
Coregulation of Androgen receptor activity
AndrogenReceptor
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (86)
1 – 10 of 86
PTK2B
Tclin
Family: Kinase
Novelty: 0.0009627
Score: 0.983
Data Source: STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00082373
Score: 0.962
Data Source: STRINGDB
VCL
Tbio
Novelty: 0.00044707
Score: 0.901
Data Source: STRINGDB
BCAR1
Tbio
Novelty: 0.00402253
Score: 0.889
Data Source: STRINGDB
PARVA
Tbio
Novelty: 0.00412394
Score: 0.885
Data Source: STRINGDB
NEDD9
Tbio
Novelty: 0.00451117
Score: 0.852
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013834
Score: 0.845
Data Source: STRINGDB
PARVB
Tbio
Novelty: 0.05250438
Score: 0.839
Data Source: STRINGDB
GIT1
Tbio
Family: Enzyme
Novelty: 0.01299019
Score: 0.821
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.0002729
Score: 0.799
Data Source: STRINGDB
Publication Statistics
PubMed Score  93.83

PubMed score by year
PubTator Score  77.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer