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Tchem
DAPK3
Death-associated protein kinase 3

Protein Summary
Description
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301264
  • ENSP00000301264
  • ENSG00000167657
  • ENST00000545797
  • ENSP00000442973

Symbol
  • ZIPK
  • DLK
  • ZIP
  • ZIPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.96
transcription factor binding site profile
0.86
protein domain
0.85
small molecule
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.76   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.76   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Programmed Cell Death
Gene Ontology Terms (37)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (62)
1 – 10 of 62
CEP170
Tbio
Novelty: 0.05342931
p_int: 0.999999916
p_ni: 8.4e-8
Score: 0.307
Data Source: BioPlex,STRINGDB
KIF2B
Tbio
Novelty: 0.09958244
p_int: 0.999999727
p_ni: 2.67e-7
p_wrong: 6e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
GPS2
Tbio
Novelty: 0.00986158
p_int: 0.999998571
p_ni: 0.000001429
Score: 0.177
Data Source: BioPlex,STRINGDB
MEAF6
Tbio
Novelty: 0.0914094
p_int: 0.999995779
p_ni: 0.000003052
p_wrong: 0.000001169
Data Source: BioPlex
TNFRSF8
Tclin
Novelty: 0.00030231
p_int: 0.999897088
p_ni: 0.000102904
p_wrong: 8e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
KLHDC3
Tdark
Novelty: 0.63840156
p_int: 0.962053413
p_ni: 0.000316784
p_wrong: 0.037629804
Score: 0.166
Data Source: BioPlex,STRINGDB
UNC5B
Tbio
Novelty: 0.01474065
Score: 0.933
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.913
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.861
Data Source: STRINGDB
BECN1
Tbio
Novelty: 0.0003792
Score: 0.859
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.76

PubMed score by year
PubTator Score  1785.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer