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Tbio
GPAA1
Glycosylphosphatidylinositol anchor attachment 1 protein

Protein Summary
Description
Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355091
  • ENSP00000347206
  • ENSG00000197858
  • ENST00000361036
  • ENSP00000354316

Symbol
  • GAA1
  • GAA1
  • hGAA1
  • GPIBD15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
kinase perturbation
0.96
disease perturbation
0.87
transcription factor binding site profile
0.7
cellular component
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.57   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.57   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (83)
1 – 10 of 83
THY1
Tbio
Novelty:  0.00032846
p_int:  0.999893691
p_ni:  0.00010631
Data Source:  BioPlex
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.999740416
p_ni:  0.000259584
Score:  0.999
Data Source:  BioPlex,STRINGDB
PIGK
Tbio
Family:  Enzyme
Novelty:  0.02333499
p_int:  0.991763982
p_ni:  0.008236018
Score:  0.999
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.98801321
p_ni:  0.01198679
Data Source:  BioPlex
CACNA2D3
Tbio
Family:  IC
Novelty:  0.05267262
p_int:  0.976120325
p_ni:  0.023879675
Data Source:  BioPlex
ART4
Tbio
Family:  Enzyme
Novelty:  0.15332159
p_int:  0.973209164
p_ni:  0.026790836
Data Source:  BioPlex
PTP4A2
Tchem
Family:  Enzyme
Novelty:  0.0083639
p_int:  0.956921576
p_ni:  0.04298222
p_wrong:  0.000096204
Score:  0.168
Data Source:  BioPlex,STRINGDB
MOXD1
Tbio
Family:  Enzyme
Novelty:  0.00571213
p_int:  0.952995329
p_ni:  0.047004671
Score:  0.238
Data Source:  BioPlex,STRINGDB
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.941329973
p_ni:  0.058670027
Data Source:  BioPlex
TCTN3
Tdark
Novelty:  0.24504659
p_int:  0.92718172
p_ni:  0.07281828
Data Source:  BioPlex
Pathways (7)
Attachment of GPI anchor to uPAR (R-HSA-162791)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attachment of GPI anchor to uPAR
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Attachment of GPI anchor to uPAR
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
2
2
90.4
blood metabolite measurement
1
2
2
89.7
low density lipoprotein cholesterol measurement
3
2
3
86.1
metabolite measurement
1
1
1
85.4
serum metabolite measurement
1
1
1
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
90.4
blood metabolite measurement
2
89.7
low density lipoprotein cholesterol measurement
3
86.1
metabolite measurement
1
85.4
serum metabolite measurement
1
84.3
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glycosylphosphatidylinositol anchor attachment 1
699887
Mouse
MGI:1202392
14731
Rat
RGD:1303197
300046
Dog
glycosylphosphatidylinositol anchor attachment 1
VGNC:41358
475120
Horse
glycosylphosphatidylinositol anchor attachment 1
VGNC:18469
100063382
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glycosylphosphatidylinositol anchor attachment 1
Mouse
Rat
Dog
glycosylphosphatidylinositol anchor attachment 1
Horse
glycosylphosphatidylinositol anchor attachment 1
Publication Statistics
PubMed Score 50.57
PubMed score by year
PubTator Score 31.43
PubTator score by year