Tbio SPINT2 Kunitz-type protease inhibitor 2

Protein Summary

Description

Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• O43291
• A8K667
• B4DLU1
• O00271
• O14895
• Q5TZQ3
• Q969E0

Gene Name

• SPINT2

Ensembl ID

• ENST00000301244
• ENSP00000301244
• ENSG00000167642
• ENST00000454580
• ENSP00000389788

Symbol

• HAI2
• KOP
• PB
• Kop
• HAI2
• DIAR3
• HAI-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
disease perturbation	0.74
PubMedID	0.67
virus	0.66
small molecule perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.1   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 346   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.1   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0