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Tbio
SPINT2
Kunitz-type protease inhibitor 2

Protein Summary
Description
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301244
  • ENSP00000301244
  • ENSG00000167642
  • ENST00000454580
  • ENSP00000389788

Symbol
  • HAI2
  • KOP
  • PB
  • Kop
  • HAI2
  • DIAR3
  • HAI-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
disease perturbation
0.74
PubMedID
0.67
virus
0.66
small molecule perturbation
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
PRR14
Tbio
Novelty:  0.22401806
p_int:  0.999999615
p_ni:  3.85e-7
Data Source:  BioPlex
ELF2
Tbio
Family:  TF
Novelty:  0.01302604
p_int:  0.999984681
p_ni:  0.000015317
p_wrong:  2e-9
Data Source:  BioPlex
SCARF2
Tbio
Novelty:  0.08833851
p_int:  0.999041173
p_ni:  0.000881916
p_wrong:  0.000076911
Data Source:  BioPlex
KIF14
Tbio
Novelty:  0.02313641
p_int:  0.999011658
p_ni:  0.000988342
Score:  0.168
Data Source:  BioPlex,STRINGDB
LIN54
Tbio
Novelty:  0.06173892
p_int:  0.998816932
p_ni:  0.001182958
p_wrong:  1.11e-7
Data Source:  BioPlex
CNTNAP1
Tbio
Novelty:  0.00618741
p_int:  0.998000934
p_ni:  0.001953541
p_wrong:  0.000045525
Score:  0.151
Data Source:  BioPlex,STRINGDB
NFRKB
Tbio
Novelty:  0.13445983
p_int:  0.997221299
p_ni:  0.002778701
Data Source:  BioPlex
LRIF1
Tdark
Novelty:  0.26861958
p_int:  0.996821961
p_ni:  0.003178039
Data Source:  BioPlex
PKMYT1
Tchem
Family:  Kinase
Novelty:  0.03025516
p_int:  0.996498776
p_ni:  0.00035109
p_wrong:  0.003150134
Data Source:  BioPlex
FNDC3B
Tbio
Novelty:  0.03060075
p_int:  0.996474884
p_ni:  0.000051808
p_wrong:  0.003473308
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
MET Receptor Activation (R-HSA-6806942)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET Receptor Activation
Reactome
Signal Transduction
Reactome
Signaling by MET
Reactome
Signaling by MST1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
MET Receptor Activation
Signal Transduction
Signaling by MET
Signaling by MST1
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.1
92.5
mean platelet volume
3
3
3
92.3
platelet count
2
2
2
85.2
calcium measurement
1
1
1
63.7
serum gamma-glutamyl transferase measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.5
mean platelet volume
3
92.3
platelet count
2
85.2
calcium measurement
1
63.7
serum gamma-glutamyl transferase measurement
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kunitz type 2
VGNC:14755
468863
Macaque
serine peptidase inhibitor, Kunitz type 2
714755
Mouse
MGI:1338031
20733
Rat
RGD:735123
292770
Dog
serine peptidase inhibitor, Kunitz type 2
VGNC:53991
403665
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kunitz type 2
Macaque
serine peptidase inhibitor, Kunitz type 2
Mouse
Rat
Dog
serine peptidase inhibitor, Kunitz type 2
Publication Statistics
PubMed Score 238.00
PubMed score by year
PubTator Score 104.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title