Tbio SART1 U4/U6.U5 tri-snRNP-associated protein 1

Protein Summary

Description

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43290
• A6NDN1
• Q53GB5

Gene Name

• SART1

Ensembl ID

• ENST00000312397
• ENSP00000310448
• ENSG00000175467

Symbol

• HAF
• Ara1
• HOMS1
• Snu66
• SART1259
• SNRNP110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
hub protein	0.79
histone modification site profile	0.72
biological process	0.67
tissue	0.65

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / U4/u6.u5 Tri-snrnp-associated Protein 1

DTO Classes

Protein / Extracellular Structure / U4/u6.u5 Tri-snrnp-associated Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.01   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.01   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0