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Tchem
MAP3K13
Mitogen-activated protein kinase kinase kinase 13

Protein Summary
Description
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265026
  • ENSP00000265026
  • ENSG00000073803
  • ENST00000424227
  • ENSP00000399910
  • ENST00000433092
  • ENSP00000389798
  • ENST00000438053
  • ENSP00000403561
  • ENST00000443863
  • ENSP00000409325
  • ENST00000446828
  • ENSP00000411483

Symbol
  • LZK
  • LZK
  • MLK
  • MEKK13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
virus perturbation
0.79
histone modification site profile
0.76
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (36)
HIST2H2AC
Tbio
Novelty:  0.00065524
p_int:  0.999575675
p_ni:  0.000424325
Score:  0.327
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.997332192
p_ni:  0.002667808
Score:  0.206
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.993939368
p_ni:  0.006024169
p_wrong:  0.000036463
Score:  0.183
Data Source:  BioPlex,STRINGDB
MAP2K7
Tchem
Family:  Kinase
Novelty:  0.00916401
Score:  0.953
Data Source:  STRINGDB
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
Score:  0.815
Data Source:  STRINGDB
MAPK8IP2
Tbio
Family:  Enzyme
Novelty:  0.01788453
Score:  0.791
Data Source:  STRINGDB
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
Score:  0.631
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.59
Data Source:  STRINGDB
FBXO45
Tbio
Novelty:  0.05784607
Score:  0.586
Data Source:  STRINGDB
TMEM41A
Tdark
Novelty:  1.49362751
Score:  0.583
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
2
3
40.4
glomerular filtration rate
1
1
1
33
sex hormone-binding globulin measurement
2
1
2
13.4
urate measurement
1
1
1
7.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
40.4
glomerular filtration rate
1
33
sex hormone-binding globulin measurement
2
13.4
urate measurement
1
7.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 13
VGNC:11985
737524
Macaque
mitogen-activated protein kinase kinase kinase 13
701085
Mouse
MGI:2444243
71751
Rat
RGD:1561227
303823
Dog
mitogen-activated protein kinase kinase kinase 13
VGNC:42969
100685499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 13
Macaque
mitogen-activated protein kinase kinase kinase 13
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 13
Publication Statistics
PubMed Score 200.04
PubMed score by year
PubTator Score 34.56
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title