Tbio SPINT1 Kunitz-type protease inhibitor 1

Protein Summary

Description

Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43278
• Q7Z7D2

Gene Name

• SPINT1

Ensembl ID

• ENST00000344051
• ENSP00000342098
• ENSG00000166145
• ENST00000562057
• ENSP00000457076

Symbol

• HAI1
• HAI
• HAI1
• MANSC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
protein domain	0.85
PubMedID	0.83
transcription factor perturbation	0.74
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.18   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 376   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.18   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0