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Tbio
SPINT1
Kunitz-type protease inhibitor 1

Protein Summary
Description
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344051
  • ENSP00000342098
  • ENSG00000166145
  • ENST00000562057
  • ENSP00000457076

Symbol
  • HAI1
  • HAI
  • HAI1
  • MANSC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
protein domain
0.85
PubMedID
0.83
transcription factor perturbation
0.74
disease perturbation
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.09   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.09   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kunitz type 1
VGNC:8288
453342
Mouse
MGI:1338033
20732
Rat
RGD:1303138
311331
Dog
serine peptidase inhibitor, Kunitz type 1
VGNC:46746
487501
Horse
serine peptidase inhibitor, Kunitz type 1
VGNC:23524
100071304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kunitz type 1
Mouse
Rat
Dog
serine peptidase inhibitor, Kunitz type 1
Horse
serine peptidase inhibitor, Kunitz type 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43278-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
MET Receptor Activation (R-HSA-6806942)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET Receptor Activation
Reactome
Signal Transduction
Reactome
Signaling by MET
Reactome
Signaling by MST1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
MET Receptor Activation
Signal Transduction
Signaling by MET
Signaling by MST1
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (59)
1 – 10 of 59
ZNF250
Tdark
Family: TF
Novelty: 2.37207478
p_int: 0.999816641
p_ni: 0.000061395
p_wrong: 0.000121963
Score: 0.685
Data Source: BioPlex,STRINGDB
ST14
Tchem
Novelty: 0.00278331
Score: 0.996
Data Source: STRINGDB
HGFAC
Tchem
Family: Enzyme
Novelty: 0.00620243
Score: 0.988
Data Source: STRINGDB
HGF
Tchem
Family: Enzyme
Novelty: 0.00035574
Score: 0.964
Data Source: STRINGDB
MST1
Tbio
Family: Enzyme
Novelty: 0.00781564
Score: 0.936
Data Source: STRINGDB
PRSS8
Tchem
Family: Enzyme
Novelty: 0.00898162
Score: 0.916
Data Source: STRINGDB
HPN
Tchem
Family: Enzyme
Novelty: 0.00713738
Score: 0.781
Data Source: STRINGDB
CLDN7
Tbio
Novelty: 0.00722366
Score: 0.73
Data Source: STRINGDB
TMPRSS13
Tbio
Family: Enzyme
Novelty: 0.01107136
Score: 0.637
Data Source: STRINGDB
NAGLU
Tbio
Family: Enzyme
Novelty: 0.01033079
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.09

PubMed score by year
PubTator Score  119.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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