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Tbio
SPINT1
Kunitz-type protease inhibitor 1

Protein Summary
Description
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344051
  • ENSP00000342098
  • ENSG00000166145
  • ENST00000562057
  • ENSP00000457076

Symbol
  • HAI1
  • HAI
  • HAI1
  • MANSC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
protein domain
0.85
PubMedID
0.83
transcription factor perturbation
0.74
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.37   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.37   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
ZNF250
Tdark
Family:  TF
Novelty:  2.37207478
p_int:  0.999816641
p_ni:  0.000061395
p_wrong:  0.000121963
Score:  0.685
Data Source:  BioPlex,STRINGDB
ST14
Tchem
Novelty:  0.00278331
Score:  0.996
Data Source:  STRINGDB
HGFAC
Tchem
Family:  Enzyme
Novelty:  0.00620243
Score:  0.988
Data Source:  STRINGDB
HGF
Tchem
Family:  Enzyme
Novelty:  0.00035574
Score:  0.964
Data Source:  STRINGDB
MST1
Tchem
Family:  Enzyme
Novelty:  0.00781564
Score:  0.936
Data Source:  STRINGDB
PRSS8
Tchem
Family:  Enzyme
Novelty:  0.00898162
Score:  0.916
Data Source:  STRINGDB
HPN
Tchem
Family:  Enzyme
Novelty:  0.00713738
Score:  0.781
Data Source:  STRINGDB
CLDN7
Tbio
Novelty:  0.00722366
Score:  0.73
Data Source:  STRINGDB
TMPRSS13
Tbio
Family:  Enzyme
Novelty:  0.01107136
Score:  0.637
Data Source:  STRINGDB
NAGLU
Tbio
Family:  Enzyme
Novelty:  0.01033079
Score:  0.626
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
MET Receptor Activation (R-HSA-6806942)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET Receptor Activation
Reactome
Signal Transduction
Reactome
Signaling by MET
Reactome
Signaling by MST1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
MET Receptor Activation
Signal Transduction
Signaling by MET
Signaling by MST1
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
1
1
5.7
45.2
cognitive function measurement
3
1
3
40.7
self reported educational attainment
1
1
1
33.1
sex hormone-binding globulin measurement
1
1
1
31.4
hemoglobin measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
5.7
45.2
cognitive function measurement
3
40.7
self reported educational attainment
1
33.1
sex hormone-binding globulin measurement
1
31.4
hemoglobin measurement
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kunitz type 1
VGNC:8288
453342
Mouse
MGI:1338033
20732
Rat
RGD:1303138
311331
Dog
serine peptidase inhibitor, Kunitz type 1
VGNC:46746
487501
Horse
serine peptidase inhibitor, Kunitz type 1
VGNC:23524
100071304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kunitz type 1
Mouse
Rat
Dog
serine peptidase inhibitor, Kunitz type 1
Horse
serine peptidase inhibitor, Kunitz type 1
Publication Statistics
PubMed Score 137.37
PubMed score by year
PubTator Score 119.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title