PRODH
Proline dehydrogenase 1, mitochondrial
Protein Summary
Converts proline to delta-1-pyrroline-5-carboxylate. This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
- ENST00000357068
- ENSP00000349577
- ENSG00000100033
- PIG6
- POX2
- PRODH2
- POX
- PIG6
- HSPOX2
- PRODH1
- PRODH2
- TP53I6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.72 | ||
cellular component | 0.7 | ||
disease | 0.61 | ||
transcription factor perturbation | 0.61 | ||
molecular function | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 255.33 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 288 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 255.33 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 288 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0