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Tbio
ZW10
Centromere/kinetochore protein zw10 homolog

Protein Summary
Description
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200135
  • ENSP00000200135
  • ENSG00000086827
  • ENST00000535142
  • ENSP00000440879

Symbol
  • HZW10
  • KNTC1AP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
interacting protein
0.98
tissue sample
0.81
disease perturbation
0.79
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.16   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.16   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (222)
RINT1
Tbio
Novelty:  0.04546291
p_int:  0.999973445
p_ni:  0.000026555
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SCFD2
Tdark
Novelty:  0.38252131
p_int:  0.999799681
p_ni:  0.000200319
Score:  0.942
Data Source:  BioPlex,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.986892875
p_ni:  0.013107124
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
USE1
Tbio
Novelty:  0.00904756
p_int:  0.985396769
p_ni:  0.014603231
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.966225469
p_ni:  0.033774531
Data Source:  BioPlex
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.96145128
p_ni:  0.03854872
Data Source:  BioPlex
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.93552475
p_ni:  0.06447525
Score:  0.98
Data Source:  BioPlex,STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.916241521
p_ni:  0.083758479
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.912142121
p_ni:  0.087857879
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.882260499
p_ni:  0.117739501
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
COPI-dependent Golgi-to-ER retrograde traffic
Cell Cycle
Cell Cycle Checkpoints
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
4
4
4
64.3
smoking status measurement
2
1
2
57.3
Age-related nuclear cataract
1
1
0
6.3
40.7
self reported educational attainment
1
1
1
31.4
parental longevity
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
4
64.3
smoking status measurement
2
57.3
Age-related nuclear cataract
0
6.3
40.7
self reported educational attainment
1
31.4
parental longevity
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zw10 kinetochore protein
VGNC:930
451554
Macaque
zw10 kinetochore protein
694436
Mouse
MGI:1349478
26951
Rat
RGD:1309197
363059
Dog
zw10 kinetochore protein
VGNC:48864
479433
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zw10 kinetochore protein
Macaque
zw10 kinetochore protein
Mouse
Rat
Dog
zw10 kinetochore protein
Publication Statistics
PubMed Score 58.16
PubMed score by year
PubTator Score 31.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title