Tbio ZNHIT1 Zinc finger HIT domain-containing protein 1

Protein Summary

Description

Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.

Uniprot Accession IDs

• O43257
• Q6IB12

Gene Name

• ZNHIT1

Ensembl ID

• ENST00000305105
• ENSP00000304593
• ENSG00000106400

Symbol

• CGBP1
• ZNFN4A1
• CG1I
• ZNFN4A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
histone modification site profile	0.91
kinase perturbation	0.88
transcription factor perturbation	0.68
gene perturbation	0.65

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Hit Domain-containing Protein 1

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Hit Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.81   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.81   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0