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Tbio
SIAH2
E3 ubiquitin-protein ligase SIAH2

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated deg ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312960
  • ENSP00000322457
  • ENSG00000181788

Symbol
  • hSiah2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
protein domain
0.92
kinase perturbation
0.88
PubMedID
0.86
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.01   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.01   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
24.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
siah E3 ubiquitin protein ligase 2
VGNC:2564
460781
Macaque
siah E3 ubiquitin protein ligase 2
710222
Mouse
MGI:108062
20439
Rat
RGD:620778
140593
Horse
siah E3 ubiquitin protein ligase 2
VGNC:22973
100034000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
siah E3 ubiquitin protein ligase 2
Macaque
siah E3 ubiquitin protein ligase 2
Mouse
Rat
Horse
siah E3 ubiquitin protein ligase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43255-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amyloid fiber formation
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Axon guidance
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Axon guidance
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (346)
1 – 10 of 346
PRR20E
Tdark
p_int:  0.999999923
p_ni:  3.5e-8
p_wrong:  4.2e-8
Score:  0.812
Data Source:  BioPlex,STRINGDB
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
p_int:  0.99970584
p_ni:  4.8e-8
p_wrong:  0.000294111
Score:  0.986
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.996521617
p_ni:  0.000008089
p_wrong:  0.003470294
Score:  0.181
Data Source:  BioPlex,STRINGDB
UBE2V2
Tbio
Novelty:  0.01112479
Score:  0.972
Data Source:  STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.972
Data Source:  STRINGDB
SH3RF1
Tbio
Family:  Enzyme
Novelty:  0.01836588
Score:  0.966
Data Source:  STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
Score:  0.966
Data Source:  STRINGDB
USP13
Tchem
Family:  Enzyme
Novelty:  0.03470844
Score:  0.964
Data Source:  Reactome,STRINGDB
UBE2E2
Tbio
Novelty:  0.02752227
Score:  0.962
Data Source:  STRINGDB
SNCAIP
Tbio
Novelty:  0.01355161
Score:  0.961
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  78.01

PubMed score by year
PubTator Score  50.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer