You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PAPSS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Protein Summary
Description
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265174
  • ENSP00000265174
  • ENSG00000138801

Symbol
  • ATPSK1
  • PAPSS
  • SK1
  • PAPSS
  • ATPSK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
0.94
protein domain
0.92
histone modification site profile
0.81
transcription factor perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.27   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.27   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43252-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Disease
Diseases of signal transduction
Glycosaminoglycan metabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (115)
1 – 10 of 115
PAPSS2
Tbio
Family: Enzyme
Novelty: 0.01538798
p_int: 0.999999986
p_ni: 1.5e-8
Score: 0.928
Data Source: BioPlex,STRINGDB
DYNC1I2
Tbio
Novelty: 0.00228615
p_int: 0.999965275
p_ni: 0.000034725
Score: 0.737
Data Source: BioPlex,STRINGDB
CCDC116
Tdark
Novelty: 0.5512552
p_int: 0.999261607
p_ni: 0.000738393
Score: 0.865
Data Source: BioPlex,STRINGDB
WDCP
Tdark
Novelty: 0.29184907
p_int: 0.998527816
p_ni: 0.001472184
Score: 0.544
Data Source: BioPlex,STRINGDB
FBLIM1
Tbio
Novelty: 0.0332985
p_int: 0.997119643
p_ni: 0.002880357
Data Source: BioPlex
FANCG
Tbio
Novelty: 0.00908902
p_int: 0.995253851
p_ni: 0.004746149
Score: 0.226
Data Source: BioPlex,STRINGDB
ODAPH
Tbio
Novelty: 0.20386223
p_int: 0.987891411
p_ni: 0.012108589
Data Source: BioPlex
MCRIP2
Tdark
Novelty: 1.50465727
p_int: 0.984184795
p_ni: 0.015815204
p_wrong: 1e-9
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.931883034
p_ni: 0.068116966
Data Source: BioPlex
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
p_int: 0.919850528
p_ni: 0.080149472
Score: 0.16
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  53.27

PubMed score by year
PubTator Score  19.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer