Tbio PAPSS1 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Protein Summary

Description

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O43252
• O43841
• O75332
• Q6IAX6
• Q96FB1
• Q96TF4
• Q9P1P9
• Q9UE98
• PAPS synthase 1

Gene Name

• PAPSS1

Ensembl ID

• ENST00000265174
• ENSP00000265174
• ENSG00000138801

Symbol

• ATPSK1
• PAPSS
• SK1
• PAPSS
• ATPSK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
molecular function	0.94
protein domain	0.92
histone modification site profile	0.81
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 1

Protein / Transferase / Kinase / Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 1

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.39   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.39   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0