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Tbio
RBFOX2
RNA binding protein fox-1 homolog 2

Protein Summary
Description
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262829
  • ENSP00000262829
  • ENSG00000100320
  • ENST00000405409
  • ENSP00000384944
  • ENST00000414461
  • ENSP00000407855
  • ENST00000416721
  • ENSP00000405651
  • ENST00000438146
  • ENSP00000413035
  • ENST00000449924
  • ENSP00000391670
  • ENST00000618140
  • ENSP00000482053
  • ENSG00000277564
  • ENST00000619768
  • ENSP00000479761
  • ENST00000626107
  • ENSP00000485984
  • ENST00000627946
  • ENSP00000487477
  • ENST00000631365
  • ENSP00000485711

Symbol
  • FOX2
  • HRNBP2
  • RBM9
  • RTA
  • RTA
  • fxh
  • FOX2
  • RBM9
  • Fox-2
  • HNRBP2
  • HRNBP2
  • dJ106I20.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.88
histone modification site profile
0.86
microRNA
0.76
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.04   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.04   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
57.8
red blood cell distribution width
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
57.8
red blood cell distribution width
1
5.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR2
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Signal Transduction
Signaling by FGFR
Signaling by FGFR2
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (138)
1 – 10 of 138
TRMT61A
Tbio
Family: Enzyme
Novelty: 0.04443394
p_int: 0.999999756
p_ni: 2.44e-7
Score: 0.313
Data Source: BioPlex,STRINGDB
FAM136A
Tdark
Novelty: 0.4050275
p_int: 0.9999956
p_ni: 0.0000044
Score: 0.193
Data Source: BioPlex,STRINGDB
RBPMS
Tbio
Novelty: 0.01727259
p_int: 0.999981011
p_ni: 0.0000188
p_wrong: 1.89e-7
Score: 0.823
Data Source: BioPlex,STRINGDB
FNDC3B
Tbio
Novelty: 0.03060075
p_int: 0.999966973
p_ni: 0.000032964
p_wrong: 6.3e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
RBM38
Tbio
Novelty: 0.03491566
p_int: 0.999958089
p_ni: 0.000041318
p_wrong: 5.94e-7
Score: 0.576
Data Source: BioPlex,STRINGDB
PUM2
Tbio
Novelty: 0.01849765
p_int: 0.999932096
p_ni: 0.000067891
p_wrong: 1.3e-8
Score: 0.673
Data Source: BioPlex,STRINGDB
COPRS
Tbio
Novelty: 0.03545787
p_int: 0.99989912
p_ni: 0.000062219
p_wrong: 0.000038662
Data Source: BioPlex
PUM1
Tbio
Novelty: 0.01536723
p_int: 0.999646638
p_ni: 0.000353362
Score: 0.552
Data Source: BioPlex,STRINGDB
DPH2
Tbio
Novelty: 0.04268301
p_int: 0.999643918
p_ni: 0.000339815
p_wrong: 0.000016267
Data Source: BioPlex
JMJD4
Tbio
Novelty: 0.09951585
p_int: 0.999530414
p_ni: 0.000469232
p_wrong: 3.54e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  123.04

PubMed score by year
PubTator Score  126.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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