RBFOX2
RNA binding protein fox-1 homolog 2
Protein Summary
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefS ...more
- ENST00000262829
- ENSP00000262829
- ENSG00000100320
- ENST00000405409
- ENSP00000384944
- ENST00000414461
- ENSP00000407855
- ENST00000416721
- ENSP00000405651
- ENST00000438146
- ENSP00000413035
- ENST00000449924
- ENSP00000391670
- ENST00000618140
- ENSP00000482053
- ENSG00000277564
- ENST00000619768
- ENSP00000479761
- ENST00000626107
- ENSP00000485984
- ENST00000627946
- ENSP00000487477
- ENST00000631365
- ENSP00000485711
- FOX2
- HRNBP2
- RBM9
- RTA
- RTA
- fxh
- FOX2
- RBM9
- Fox-2
- HNRBP2
- HRNBP2
- dJ106I20.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.88 | ||
histone modification site profile | 0.86 | ||
microRNA | 0.76 | ||
interacting protein | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 160.4 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 227 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 160.4 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 227 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0