You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HOXC11
Homeobox protein Hox-C11

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000546378
  • ENSP00000446680
  • ENSG00000123388

Symbol
  • HOX3H
  • HOX3H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
biological process
0.74
protein domain
0.73
co-expressed gene
0.72
PubMedID
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (42)
1 – 10 of 42
TBX4
Tbio
Family:  TF
Novelty:  0.01370005
Score:  0.772
Data Source:  STRINGDB
TBX5
Tbio
Family:  TF
Novelty:  0.00272208
Score:  0.662
Data Source:  STRINGDB
HOXC10
Tbio
Family:  TF
Novelty:  0.02817778
Score:  0.643
Data Source:  STRINGDB
HOXC13
Tbio
Family:  TF
Novelty:  0.01749797
Score:  0.642
Data Source:  STRINGDB
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
Score:  0.592
Data Source:  STRINGDB
TBX6
Tbio
Family:  TF
Novelty:  0.01060902
Score:  0.563
Data Source:  STRINGDB
HOXC6
Tbio
Family:  TF
Novelty:  0.00991192
Score:  0.553
Data Source:  STRINGDB
TBX3
Tbio
Family:  TF
Novelty:  0.00515507
Score:  0.55
Data Source:  STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
Score:  0.543
Data Source:  STRINGDB
DUX4L7
Tdark
Novelty:  0.00860736
Score:  0.534
Data Source:  STRINGDB
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
20
55
98.5
waist circumference
2
16
16
97.7
waist-hip ratio
7
18
22
97.6
BMI-adjusted waist circumference
7
15
26
97.3
spine bone size
1
1
1
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
55
98.5
waist circumference
16
97.7
waist-hip ratio
22
97.6
BMI-adjusted waist circumference
26
97.3
spine bone size
1
82.9
Find similar targets by:
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
homeobox C11
106992375
Mouse
MGI:96193
109663
Dog
homeobox C11
100688428
Horse
homeobox C11
100062371
Cow
homeobox C11
536141
Species
Name
OMA
EggNOG
Inparanoid
Macaque
homeobox C11
Mouse
Dog
homeobox C11
Horse
homeobox C11
Cow
homeobox C11
Publication Statistics
PubMed Score 30.56
PubMed score by year
PubTator Score 11.21
PubTator score by year