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Tbio
SLC7A4
Cationic amino acid transporter 4

Protein Summary
Description
Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382932
  • ENSP00000372390
  • ENSG00000099960
  • ENST00000403586
  • ENSP00000384278

Symbol
  • VH
  • CAT4
  • CAT-4
  • HCAT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
cell type or tissue
0.59
kinase perturbation
0.54
cell line
0.53
disease
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.41   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.41   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
COQ7
Tbio
Family:  Enzyme
Novelty:  0.01010794
Score:  0.759
Data Source:  STRINGDB
SLC15A4
Tbio
Family:  Transporter
Novelty:  0.01325014
Score:  0.72
Data Source:  STRINGDB
PPIL4
Tdark
Family:  Enzyme
Novelty:  0.3737992
Score:  0.713
Data Source:  STRINGDB
DCAF5
Tdark
Novelty:  0.39565074
Score:  0.711
Data Source:  STRINGDB
SLC12A5
Tchem
Family:  Transporter
Novelty:  0.0017288
Score:  0.653
Data Source:  STRINGDB
KLHL22
Tbio
Novelty:  0.24456252
Score:  0.626
Data Source:  STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
Score:  0.622
Data Source:  STRINGDB
THAP7
Tbio
Family:  TF
Novelty:  0.37300241
Score:  0.621
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.614
Data Source:  STRINGDB
SF3A1
Tbio
Novelty:  0.03405702
Score:  0.587
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
Name
Explore in Pharos
Explore in Source
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
30.2
mean platelet volume
1
1
1
28.1
1
1
0
1.1
21.5
gut microbiome measurement
1
1
2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
30.2
mean platelet volume
1
28.1
0
1.1
21.5
gut microbiome measurement
2
15.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 4
VGNC:12922
745604
Mouse
MGI:2146512
224022
Rat
RGD:1305905
303787
Dog
solute carrier family 7 member 4
VGNC:46475
486435
Horse
cationic amino acid transporter 4-like
100051903
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 4
Mouse
Rat
Dog
solute carrier family 7 member 4
Horse
cationic amino acid transporter 4-like
Publication Statistics
PubMed Score 66.41
PubMed score by year
PubTator Score 26.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title