Protein Summary
Has a tumor-suppressor role for NES1 in breast and prostate cancer. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- ENST00000309958
- ENSP00000311746
- ENSG00000129451
- ENST00000358789
- ENSP00000351640
- ENST00000391805
- ENSP00000375681
- NES1
- PRSSL1
- NES1
- PRSSL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.81 | ||
disease perturbation | 0.74 | ||
PubMedID | 0.74 | ||
tissue sample | 0.69 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.32 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 336 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.32 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 336 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (33)
TBC1D22B
Novelty: 0.49852962
p_int: 0.999962421
p_ni: 0.000037579
p_wrong: 1e-9
Data Source: BioPlex
TEFM
Novelty: 0.10836617
p_int: 0.999832682
p_ni: 0.00016292
p_wrong: 0.000004397
Data Source: BioPlex
FTH1
Novelty: 0.000863
p_int: 0.999682273
p_ni: 0.000317726
p_wrong: 2e-9
Score: 0.154
Data Source: BioPlex,STRINGDB
TNFRSF19
Novelty: 0.01295599
p_int: 0.999660545
p_ni: 0.000202602
p_wrong: 0.000136853
Data Source: BioPlex
CCDC103
Novelty: 0.07857649
p_int: 0.999222213
p_ni: 0.000675232
p_wrong: 0.000102555
Data Source: BioPlex
GMCL1
Novelty: 0.1543762
p_int: 0.998107672
p_ni: 0.001891634
p_wrong: 6.95e-7
Data Source: BioPlex
SUSD3
Novelty: 0.43699506
p_int: 0.997516982
p_ni: 0.00164276
p_wrong: 0.000840259
Data Source: BioPlex
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.995943824
p_ni: 0.003762169
p_wrong: 0.000294007
Data Source: BioPlex
ZSCAN20
Family: TF
Novelty: 0.37441538
p_int: 0.995765863
p_ni: 0.003003386
p_wrong: 0.001230751
Data Source: BioPlex
FCF1
Novelty: 0.04202976
p_int: 0.982353837
p_ni: 0.017645974
p_wrong: 1.89e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 3 | 5 | 91.6 | |||||
blood protein measurement | 1 | 2 | 2 | 89.8 | |||||
kallikreinâ6 measurement | 1 | 1 | 1 | 87.2 | |||||
kallikrein-11 measurement | 1 | 1 | 0 | 1.5 | 69.5 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 91.6 | |||||
blood protein measurement | 2 | 89.8 | |||||
kallikreinâ6 measurement | 1 | 87.2 | |||||
kallikrein-11 measurement | 0 | 1.5 | 69.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 10 | VGNC:11147 | 748677 | |||||
Mouse | MGI:1916790 | 69540 | ||||||
Rat | RGD:1303242 | 292850 | ||||||
Dog | kallikrein related peptidase 10 | VGNC:42478 | 484351 | |||||
Cow | kallikrein related peptidase 10 | VGNC:30672 | 526736 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | kallikrein related peptidase 10 | |||||
Cow | kallikrein related peptidase 10 | |||||
Publication Statistics
PubMed Score 111.32
PubMed score by year
PubTator Score 76.20
PubTator score by year
Related Publications
Text Mined References (66)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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