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Tbio
KLK10
Kallikrein-10

Protein Summary
Description
Has a tumor-suppressor role for NES1 in breast and prostate cancer. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309958
  • ENSP00000311746
  • ENSG00000129451
  • ENST00000358789
  • ENSP00000351640
  • ENST00000391805
  • ENSP00000375681

Symbol
  • NES1
  • PRSSL1
  • NES1
  • PRSSL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
disease perturbation
0.74
PubMedID
0.74
tissue sample
0.69
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.32   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.32   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999962421
p_ni:  0.000037579
p_wrong:  1e-9
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.999832682
p_ni:  0.00016292
p_wrong:  0.000004397
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999682273
p_ni:  0.000317726
p_wrong:  2e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.999660545
p_ni:  0.000202602
p_wrong:  0.000136853
Data Source:  BioPlex
CCDC103
Tbio
Novelty:  0.07857649
p_int:  0.999222213
p_ni:  0.000675232
p_wrong:  0.000102555
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.998107672
p_ni:  0.001891634
p_wrong:  6.95e-7
Data Source:  BioPlex
SUSD3
Tdark
Novelty:  0.43699506
p_int:  0.997516982
p_ni:  0.00164276
p_wrong:  0.000840259
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.995943824
p_ni:  0.003762169
p_wrong:  0.000294007
Data Source:  BioPlex
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.995765863
p_ni:  0.003003386
p_wrong:  0.001230751
Data Source:  BioPlex
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.982353837
p_ni:  0.017645974
p_wrong:  1.89e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
3
5
91.6
blood protein measurement
1
2
2
89.8
kallikrein‐6 measurement
1
1
1
87.2
kallikrein-11 measurement
1
1
0
1.5
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
91.6
blood protein measurement
2
89.8
kallikrein‐6 measurement
1
87.2
kallikrein-11 measurement
0
1.5
69.5
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 10
VGNC:11147
748677
Mouse
MGI:1916790
69540
Rat
RGD:1303242
292850
Dog
kallikrein related peptidase 10
VGNC:42478
484351
Cow
kallikrein related peptidase 10
VGNC:30672
526736
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 10
Mouse
Rat
Dog
kallikrein related peptidase 10
Cow
kallikrein related peptidase 10
Publication Statistics
PubMed Score 111.32
PubMed score by year
PubTator Score 76.20
PubTator score by year
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Related Publications
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PMID
Year
Title