KLK10
Kallikrein-10
Protein Summary
Has a tumor-suppressor role for NES1 in breast and prostate cancer. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- ENST00000309958
- ENSP00000311746
- ENSG00000129451
- ENST00000358789
- ENSP00000351640
- ENST00000391805
- ENSP00000375681
- NES1
- PRSSL1
- NES1
- PRSSL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.81 | ||
disease perturbation | 0.74 | ||
PubMedID | 0.74 | ||
tissue sample | 0.69 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.99 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 336 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.99 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 336 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0