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Tbio
MSH5
MutS protein homolog 5

Protein Summary
Description
Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity). This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375703
  • ENSP00000364855
  • ENSG00000204410
  • ENST00000375740
  • ENSP00000364892
  • ENST00000375750
  • ENSP00000364903
  • ENST00000375755
  • ENSP00000364908
  • ENST00000412070
  • ENSP00000404892
  • ENSG00000230961
  • ENST00000416549
  • ENSP00000399721
  • ENSG00000235222
  • ENST00000419269
  • ENSP00000394649
  • ENST00000420731
  • ENSP00000400187
  • ENST00000427735
  • ENSP00000388037
  • ENSG00000230293
  • ENST00000435700
  • ENSP00000407047
  • ENST00000436091
  • ENSP00000396509
  • ENST00000436192
  • ENSP00000406868
  • ENSG00000227314
  • ENST00000441395
  • ENSP00000402659
  • ENST00000441401
  • ENSP00000406269
  • ENST00000448617
  • ENSP00000387609
  • ENST00000456839
  • ENSP00000394017
  • ENST00000457742
  • ENSP00000409181

Symbol
  • G7
  • NG23
  • POF13
  • MUTSH5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
virus perturbation
0.76
phenotype
0.74
cell line
0.64
transcription factor
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.21   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.21   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (80)
Items per page:
1 – 5 of 80
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.4
94.9
1
1
0
2.4
94.9
1
1
0
2.4
94.9
1
1
0
2.4
94.9
1
1
0
2.4
94.9
Items per page:
1 – 5 of 80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.4
94.9
0
2.4
94.9
0
2.4
94.9
0
2.4
94.9
0
2.4
94.9
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic recombination
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic recombination
Reproduction
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (147)
1 – 10 of 147
EDEM1
Tbio
Family: Enzyme
Novelty: 0.01157706
p_int: 0.999999162
p_ni: 8.34e-7
p_wrong: 4e-9
Data Source: BioPlex
MLH1
Tbio
Novelty: 0.00034212
Score: 0.994
Data Source: STRINGDB
MLH3
Tbio
Novelty: 0.01295793
Score: 0.993
Data Source: STRINGDB
RAD51
Tchem
Novelty: 0.00011516
Score: 0.983
Data Source: STRINGDB
MSH4
Tbio
Novelty: 0.00838156
Score: 0.974
Data Source: Reactome,STRINGDB
HIST1H2BD
Tbio
Novelty: 0.05094332
Score: 0.969
Data Source: STRINGDB
BLM
Tchem
Novelty: 0.00662454
Score: 0.968
Data Source: STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
Score: 0.965
Data Source: STRINGDB
DMC1
Tbio
Novelty: 0.05445277
Score: 0.964
Data Source: STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  90.21

PubMed score by year
PubTator Score  49.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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