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Tchem
GPR39
G-protein coupled receptor 39

Protein Summary
Description
Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329321
  • ENSP00000327417
  • ENSG00000183840
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
histone modification site profile
0.71
cell line
0.6
transcription factor binding site profile
0.59
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.43   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.43   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 50
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
zinc chloride
no chemical structure image available
Protein-Protein Interactions (290)
1 – 10 of 290
NTS
Tbio
Novelty:  0.00033201
Score:  0.967
Data Source:  STRINGDB
MLN
Tbio
Novelty:  0.0010297
Score:  0.963
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.943
Data Source:  STRINGDB
GHRH
Tbio
Novelty:  0.00058152
Score:  0.938
Data Source:  STRINGDB
GPR25
Tdark
Family:  GPCR
Novelty:  0.42142701
Score:  0.936
Data Source:  STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.935
Data Source:  STRINGDB
MC4R
Tclin
Family:  GPCR
Novelty:  0.00091593
Score:  0.933
Data Source:  STRINGDB
GLP1R
Tclin
Family:  GPCR
Novelty:  0.0006899
Score:  0.932
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.931
Data Source:  STRINGDB
GPR83
Tchem
Family:  GPCR
Novelty:  0.03554942
Score:  0.928
Data Source:  STRINGDB
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
79.4
self reported educational attainment
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
79.4
self reported educational attainment
1
0.8
Find similar targets by:
IDG Resources
Genetic Construct
GPR39-Tango
image for GPR39-Tango
Details:
  • Vector:  addgene66357
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR39-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 39
VGNC:10831
459623
Macaque
G protein-coupled receptor 39 [Source:HGNC Symbol;Acc:HGNC:4496]
Mouse
MGI:1918361
71111
Rat
RGD:1306745
288995
Dog
G protein-coupled receptor 39
VGNC:41434
610696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 39
Macaque
G protein-coupled receptor 39 [Source:HGNC Symbol;Acc:HGNC:4496]
Mouse
Rat
Dog
G protein-coupled receptor 39
Publication Statistics
PubMed Score 102.43
PubMed score by year
PubTator Score 51.90
PubTator score by year
Patents
Patents by year