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Tchem
MLNR
Motilin receptor

Protein Summary
Description
Receptor for motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218721
  • ENSP00000218721
  • ENSG00000102539

Symbol
  • GPR38
  • MTLR
  • MTLR1
  • GPR38
  • MTLR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.76
histone modification site profile
0.57
cell line
0.49
cell type or tissue
0.47
disease
0.46


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.63   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.63   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 180
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
benzamycin
no chemical structure image available
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
motilin receptor
VGNC:43264
608252
Cow
motilin receptor
VGNC:53824
788867
Pig
motilin receptor
100620836
Opossum
motilin receptor
100028809
Chicken
motilin receptor
CGNC:12765
428072
Species
Name
OMA
EggNOG
Inparanoid
Dog
motilin receptor
Cow
motilin receptor
Pig
motilin receptor
Opossum
motilin receptor
Chicken
motilin receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43193-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
GO_Central
Inferred from Physical Interaction (IPI)
GO_Central
Protein-Protein Interactions (184)
1 – 10 of 184
MLN
Tbio
Novelty:  0.0010297
Score:  0.994
Data Source:  Reactome,STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.949
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.945
Data Source:  STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.935
Data Source:  STRINGDB
NMU
Tbio
Novelty:  0.00326109
Score:  0.933
Data Source:  STRINGDB
GPR39
Tchem
Family:  GPCR
Novelty:  0.01244607
Score:  0.925
Data Source:  STRINGDB
NMBR
Tchem
Family:  GPCR
Novelty:  0.01642469
Score:  0.921
Data Source:  STRINGDB
LPAR6
Tchem
Family:  GPCR
Novelty:  0.01801122
Score:  0.92
Data Source:  STRINGDB
TACR2
Tchem
Family:  GPCR
Novelty:  0.00194306
Score:  0.918
Data Source:  STRINGDB
HCRT
Tbio
Novelty:  0.00034048
Score:  0.918
Data Source:  STRINGDB
Publication Statistics
PubMed Score  189.63

PubMed score by year
PubTator Score  34.38

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer