Tchem MLNR Motilin receptor

Protein Summary

Description

Receptor for motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O43193

Gene Name

• MLNR

Ensembl ID

• ENST00000218721
• ENSP00000218721
• ENSG00000102539

Symbol

• GPR38
• MTLR
• MTLR1
• GPR38
• MTLR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.76
histone modification site profile	0.57
cell line	0.49
cell type or tissue	0.47
disease	0.46

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Motilin Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Motilin Receptor / Motilin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.33   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.33   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 180

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1