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Tbio
PHF1
PHD finger protein 1

Protein Summary
Description
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. This gene encodes a Polycomb group protein. The protein is a component of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374512
  • ENSP00000363636
  • ENSG00000112511
  • ENST00000374516
  • ENSP00000363640
  • ENST00000427869
  • ENSP00000391901
  • ENSG00000225553
  • ENST00000454914
  • ENSP00000407295

Symbol
  • PCL1
  • PCL1
  • PHF2
  • hPHF1
  • MTF2L2
  • TDRD19C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.88
cell type or tissue
0.76
biological process
0.73
histone modification site profile
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.25   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.25   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PHD finger protein 1
718337
Mouse
MGI:98647
21652
Rat
RGD:1303205
294287
Dog
PHD finger protein 1
VGNC:44479
481741
Horse
PHD finger protein 1
VGNC:21372
100061619
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PHD finger protein 1
Mouse
Rat
Dog
PHD finger protein 1
Horse
PHD finger protein 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43189-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Epigenetic regulation of gene expression (R-HSA-212165)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
PRC2 methylates histones and DNA
Name
Explore in Pharos
Explore in Source
Epigenetic regulation of gene expression
Gene expression (Transcription)
PRC2 methylates histones and DNA
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (110)
1 – 10 of 110
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
p_int: 0.999999944
p_ni: 5.2e-8
p_wrong: 3e-9
Score: 0.977
Data Source: BioPlex,Reactome,STRINGDB
SUZ12
Tbio
Novelty: 0.00402353
p_int: 0.999999919
p_ni: 5.8e-8
p_wrong: 2.3e-8
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.999999322
p_ni: 6.55e-7
p_wrong: 2.4e-8
Data Source: BioPlex
CALCA
Tclin
Novelty: 0.00010496
p_int: 0.999635156
p_ni: 0.000152635
p_wrong: 0.000212209
Data Source: BioPlex
PROSER2
Tdark
Novelty: 0.56334611
p_int: 0.999415824
p_ni: 0.000001755
p_wrong: 0.000582421
Score: 0.243
Data Source: BioPlex,STRINGDB
DNAJB3
Tdark
p_int: 0.828329409
p_ni: 0.000718072
p_wrong: 0.170952519
Data Source: BioPlex
RBBP4
Tbio
Novelty: 0.01062843
Score: 0.974
Data Source: Reactome,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
Score: 0.972
Data Source: Reactome,STRINGDB
EED
Tchem
Novelty: 0.00615758
Score: 0.971
Data Source: Reactome,STRINGDB
AEBP2
Tbio
Novelty: 0.05974483
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  215.25

PubMed score by year
PubTator Score  392.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer