Tbio IRAK2 Interleukin-1 receptor-associated kinase-like 2

Protein Summary

Description

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43187
• B4DQZ6
• Q08AG6
• Q5K546
• IRAK-2

Gene Name

• IRAK2

Ensembl ID

• ENST00000256458
• ENSP00000256458
• ENSG00000134070

Symbol

• IRAK-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
biological process	0.91
transcription factor binding site profile	0.76
histone modification site profile	0.75
disease	0.7

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Irak Family / Interleukin-1 Receptor-associated Kinase-like 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.96   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 644   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.96   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0