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Tbio
IRAK2
Interleukin-1 receptor-associated kinase-like 2

Protein Summary
Description
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256458
  • ENSP00000256458
  • ENSG00000134070

Symbol
  • IRAK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.91
transcription factor binding site profile
0.76
histone modification site profile
0.75
disease
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.29   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 644   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.29   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
4
87.3
eosinophil percentage of leukocytes
2
3
3
58
eosinophil percentage of granulocytes
1
1
1
20.9
sum of eosinophil and basophil counts
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
87.3
eosinophil percentage of leukocytes
3
58
eosinophil percentage of granulocytes
1
20.9
sum of eosinophil and basophil counts
1
11.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (284)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IRAK2 mediated activation of TAK1 complex
Reactome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Immune System
Innate Immune System
Protein-Protein Interactions (105)
1 – 10 of 105
TRAF6
Tbio
Novelty: 0.00109366
p_int: 0.999999799
p_ni: 1.86e-7
p_wrong: 1.4e-8
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
SESTD1
Tbio
Novelty: 0.2052002
p_int: 0.99998282
p_ni: 0.00001718
Score: 0.269
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.817502636
p_ni: 0.182497364
Score: 0.155
Data Source: BioPlex,STRINGDB
N4BP2L2
Tbio
Novelty: 0.24527466
p_int: 0.756662129
p_ni: 0.239912216
p_wrong: 0.003425655
Score: 0.189
Data Source: BioPlex,STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.999
Data Source: Reactome,STRINGDB
IRAK4
Tchem
Family: Kinase
Novelty: 0.00344058
Score: 0.996
Data Source: Reactome,STRINGDB
TOLLIP
Tbio
Novelty: 0.01032371
Score: 0.987
Data Source: STRINGDB
IRAK3
Tchem
Family: Kinase
Novelty: 0.01001206
Score: 0.985
Data Source: STRINGDB
TIRAP
Tbio
Novelty: 0.00600495
Score: 0.981
Data Source: Reactome,STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.98
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  60.29

PubMed score by year
PubTator Score  29.54

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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