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Tchem
ADAM12
Disintegrin and metalloproteinase domain-containing protein 12

Protein Classes
Protein Summary
Description
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368676
  • ENSP00000357665
  • ENSG00000148848
  • ENST00000368679
  • ENSP00000357668

Symbol
  • MLTN
  • MCMP
  • MLTN
  • CAR10
  • MLTNA
  • MCMPMltna
  • ADAM12-OT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
protein domain
0.92
transcription factor perturbation
0.88
kinase perturbation
0.84
gene perturbation
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.62   (req: < 5)
Gene RIFs: 130   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.62   (req: >= 5)
Gene RIFs: 130   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
72.1
red blood cell distribution width
1
1
1
44.2
intelligence
1
1
0
1.5
26.6
intraocular pressure measurement
1
1
1
21.5
influenza A (H1N1)
1
1
0
4.3
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
72.1
red blood cell distribution width
1
44.2
intelligence
0
1.5
26.6
intraocular pressure measurement
1
21.5
influenza A (H1N1)
0
4.3
15.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 12
VGNC:11619
450818
Macaque
ADAM metallopeptidase domain 12
696405
Mouse
MGI:105378
11489
Rat
RGD:1583652
679837
Dog
ADAM metallopeptidase domain 12
VGNC:37574
100686018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 12
Macaque
ADAM metallopeptidase domain 12
Mouse
Rat
Dog
ADAM metallopeptidase domain 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43184-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Invadopodia formation
Reactome
Signal Transduction
Reactome
Signaling by EGFR
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Invadopodia formation
Signal Transduction
Signaling by EGFR
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (72)
1 – 10 of 72
EGF
Tbio
Novelty:  0.00010809
Score:  0.965
Data Source:  Reactome,STRINGDB
SH3PXD2A
Tbio
Novelty:  0.0252753
Score:  0.946
Data Source:  Reactome,STRINGDB
DLL1
Tbio
Novelty:  0.00150384
Score:  0.928
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.928
Data Source:  STRINGDB
ITGA9
Tbio
Novelty:  0.01488635
Score:  0.928
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.923
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.9
Data Source:  STRINGDB
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
Score:  0.9
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.742
Data Source:  STRINGDB
PAPPA
Tbio
Novelty:  0.00062817
Score:  0.73
Data Source:  STRINGDB
Publication Statistics
PubMed Score  267.62

PubMed score by year
PubTator Score  191.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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