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Tclin
NDUFS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296684
  • ENSP00000296684
  • ENSG00000164258

Symbol
  • AQDQ
  • CI-18
  • MC1DN1
  • CI-AQDQ
  • CI-18 kDa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
disease perturbation
0.9
kinase perturbation
0.88
histone modification site profile
0.86
protein complex
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.05   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.05   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
60
BMI-adjusted waist circumference
1
1
2
11.3
physical activity measurement
1
1
2
11.3
hair color
1
1
0
1.1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
60
BMI-adjusted waist circumference
2
11.3
physical activity measurement
2
11.3
hair color
0
1.1
6.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit S4
VGNC:4096
461878
Macaque
NADH:ubiquinone oxidoreductase subunit S4
704137
Mouse
MGI:1343135
17993
Rat
RGD:1594380
499529
Dog
NADH:ubiquinone oxidoreductase subunit S4
VGNC:52003
479335
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit S4
Macaque
NADH:ubiquinone oxidoreductase subunit S4
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit S4
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43181-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (184)
1 – 10 of 184
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999999537
p_ni: 4.63e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.99999818
p_ni: 0.000001815
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999998116
p_ni: 0.000001884
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.999989397
p_ni: 0.000010602
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.999986166
p_ni: 0.000013825
p_wrong: 9e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.13020753
p_int: 0.999944528
p_ni: 0.000055472
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999933264
p_ni: 0.000023318
p_wrong: 0.000043418
Score: 0.999
Data Source: BioPlex,STRINGDB
PRRT2
Tbio
Novelty: 0.00442931
p_int: 0.99972874
p_ni: 0.000262278
p_wrong: 0.000008981
Score: 0.209
Data Source: BioPlex,STRINGDB
NDUFA13
Tclin
Family: Enzyme
Novelty: 0.01605077
p_int: 0.999542861
p_ni: 0.00041259
p_wrong: 0.000044549
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA9
Tclin
Family: Enzyme
Novelty: 0.00637307
p_int: 0.999505221
p_ni: 0.000471064
p_wrong: 0.000023715
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  144.05

PubMed score by year
PubTator Score  105.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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