Tchem CYP26A1 Cytochrome P450 26A1

Protein Summary

Description

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43174
• B3KNI4
• Q5VXH9
• Q5VXI0

Gene Name

• CYP26A1

Ensembl ID

• ENST00000224356
• ENSP00000224356
• ENSG00000095596
• ENST00000371531
• ENSP00000360586

Symbol

• CYP26
• P450RAI1
• CP26
• CYP26
• P450RAI
• P450RAI1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
pathway	0.91
PubMedID	0.9
molecular function	0.86
cell type or tissue	0.82

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Cytochrome P450 26a1

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Cytochrome P450 26a1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.39   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.39   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 118

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0