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Tbio
ST8SIA3
Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

Protein Summary
Description
Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324000
  • ENSP00000320431
  • ENSG00000177511

Symbol
  • SIAT8C
  • SIAT8C
  • ST8SiaIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.86
pathway
0.85
disease perturbation
0.74
cell line
0.72
cell type or tissue
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.98   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.98   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.999097098
p_ni:  0.000902886
p_wrong:  1.6e-8
Data Source:  BioPlex
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.998873805
p_ni:  0.001126022
p_wrong:  1.73e-7
Score:  0.641
Data Source:  BioPlex,STRINGDB
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.990972766
p_ni:  0.009027234
Data Source:  BioPlex
NRP2
Tbio
Novelty:  0.00764179
p_int:  0.98429353
p_ni:  0.01570647
Score:  0.219
Data Source:  BioPlex,STRINGDB
TMEM11
Tbio
Novelty:  0.00067837
p_int:  0.938540287
p_ni:  0.01663876
p_wrong:  0.044820953
Data Source:  BioPlex
ITGB5
Tbio
Novelty:  0.01455909
p_int:  0.923130414
p_ni:  0.076527755
p_wrong:  0.000341831
Score:  0.169
Data Source:  BioPlex,STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.902360939
p_ni:  0.005074181
p_wrong:  0.09256488
Score:  0.172
Data Source:  BioPlex,STRINGDB
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
p_int:  0.858764455
p_ni:  0.141235428
p_wrong:  1.17e-7
Data Source:  BioPlex
DNAJB9
Tbio
Novelty:  0.00536296
p_int:  0.822434087
p_ni:  0.177565912
Data Source:  BioPlex
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
p_int:  0.763227073
p_ni:  0.236698428
p_wrong:  0.0000745
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
N-Glycan antennae elongation
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
N-Glycan antennae elongation
N-glycan antennae elongation in the medial/trans-Golgi
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
3
4
90.4
aspartate aminotransferase measurement
1
1
0
14.1
83.4
sex hormone-binding globulin measurement
6
2
6
79.5
alkaline phosphatase measurement
1
1
1
21.4
alcohol consumption measurement
2
1
2
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
90.4
aspartate aminotransferase measurement
0
14.1
83.4
sex hormone-binding globulin measurement
6
79.5
alkaline phosphatase measurement
1
21.4
alcohol consumption measurement
2
4.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
698407
Mouse
MGI:106019
20451
Rat
RGD:3680
25547
Dog
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
VGNC:53994
612940
Horse
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
VGNC:50977
100053917
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Mouse
Rat
Dog
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Horse
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Publication Statistics
PubMed Score 14.98
PubMed score by year
PubTator Score 5.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title