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Tbio
CYB5B
Cytochrome b5 type B

Protein Summary
Description
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000512062
  • ENSP00000423679
  • ENSG00000103018

Symbol
  • CYB5M
  • OMB5
  • OMB5
  • CYB5-M
  • CYPB5M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.88
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
2
5
96.9
urate measurement
3
2
4
85.6
cigarettes per day measurement
2
2
2
81.8
smoking initiation
2
2
2
75.5
waist-hip ratio
2
1
2
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
96.9
urate measurement
4
85.6
cigarettes per day measurement
2
81.8
smoking initiation
2
75.5
waist-hip ratio
2
47.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 type B
VGNC:9029
454202
Macaque
cytochrome b5 type B (outer mitochondrial membrane)
705093
Mouse
MGI:1913677
66427
Rat
RGD:621551
80773
Horse
cytochrome b5 type B
VGNC:50460
100067168
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 type B
Macaque
cytochrome b5 type B (outer mitochondrial membrane)
Mouse
Rat
Horse
cytochrome b5 type B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43169-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (137)
1 – 10 of 137
KIAA1586
Tdark
Novelty: 2.30999532
p_int: 0.999997868
p_ni: 0.000002132
Data Source: BioPlex
GDE1
Tbio
Family: Enzyme
Novelty: 0.05854843
p_int: 0.999978897
p_ni: 0.000003035
p_wrong: 0.000018068
Data Source: BioPlex
NR3C1
Tclin
Family: NR
Novelty: 0.00029396
p_int: 0.99996607
p_ni: 0.00003393
Data Source: BioPlex
XPO7
Tbio
Novelty: 0.05412704
p_int: 0.999936739
p_ni: 0.000063261
Data Source: BioPlex
DCUN1D5
Tdark
Novelty: 0.56719852
p_int: 0.999915515
p_ni: 0.000084477
p_wrong: 7e-9
Data Source: BioPlex
THADA
Tbio
Novelty: 0.06983966
p_int: 0.999899664
p_ni: 0.000100336
Data Source: BioPlex
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
p_int: 0.999875524
p_ni: 0.000124476
Data Source: BioPlex
USP24
Tbio
Family: Enzyme
Novelty: 0.07281326
p_int: 0.999820346
p_ni: 0.000179654
Data Source: BioPlex
KIAA0391
Tbio
Family: Enzyme
Novelty: 0.02276396
p_int: 0.999548183
p_ni: 0.000451817
Data Source: BioPlex
XPO6
Tbio
Novelty: 0.03229708
p_int: 0.999476655
p_ni: 0.000523345
Score: 0.203
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.44

PubMed score by year
PubTator Score  7.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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