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Tbio
PJA2
E3 ubiquitin-protein ligase Praja-2

Protein Summary
Description
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361189
  • ENSP00000354775
  • ENSG00000198961
  • ENST00000361557
  • ENSP00000355284

Symbol
  • KIAA0438
  • RNF131
  • RNF131
  • Neurodap1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor binding site profile
0.83
histone modification site profile
0.77
transcription factor perturbation
0.74
microRNA
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.11   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.11   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (304)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.991105273
p_ni:  0.00889472
p_wrong:  7e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
ARHGAP36
Tbio
Family:  Enzyme
Novelty:  0.33342126
p_int:  0.983998064
p_ni:  0.016001934
p_wrong:  3e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.816873788
p_ni:  0.183126212
Score:  0.173
Data Source:  BioPlex,STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.971
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.956
Data Source:  STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
Score:  0.948
Data Source:  STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
Score:  0.947
Data Source:  STRINGDB
UBE2O
Tbio
Novelty:  0.07084123
Score:  0.942
Data Source:  STRINGDB
HECTD1
Tbio
Family:  Enzyme
Novelty:  0.28016112
Score:  0.942
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
78.6
body mass index
1
1
1
46.5
educational attainment
1
1
1
3.8
high density lipoprotein cholesterol measurement
1
1
1
1.1
apolipoprotein A 1 measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
78.6
body mass index
1
46.5
educational attainment
1
3.8
high density lipoprotein cholesterol measurement
1
1.1
apolipoprotein A 1 measurement
1
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
praja ring finger ubiquitin ligase 2
VGNC:7101
471597
Macaque
praja ring finger ubiquitin ligase 2
705109
Mouse
MGI:2159342
224938
Rat
RGD:620273
192256
Dog
praja ring finger ubiquitin ligase 2
VGNC:44595
479143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
praja ring finger ubiquitin ligase 2
Macaque
praja ring finger ubiquitin ligase 2
Mouse
Rat
Dog
praja ring finger ubiquitin ligase 2
Publication Statistics
PubMed Score 13.11
PubMed score by year
PubTator Score 8.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title