Tbio RRP8 Ribosomal RNA-processing protein 8

Protein Summary

Description

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Uniprot Accession IDs

• O43159
• Q7KZ78
• Q9BVM6

Gene Name

• RRP8

Ensembl ID

• ENST00000254605
• ENSP00000254605
• ENSG00000132275

Symbol

• KIAA0409
• NML
• NML
• KIAA0409

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
biological process	0.78
transcription factor binding site profile	0.76
cellular component	0.65
tissue sample	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.81   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.81   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0