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Tbio
PLXNB1
Plexin-B1

Protein Summary
Description
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296440
  • ENSP00000296440
  • ENSG00000164050
  • ENST00000358536
  • ENSP00000351338
  • ENST00000449094
  • ENSP00000395987
  • ENST00000456774
  • ENSP00000414199

Symbol
  • KIAA0407
  • PLXN5
  • SEP
  • SEP
  • PLXN5
  • PLEXIN-B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
tissue sample
0.77
transcription factor
0.76
tissue
0.72
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.92   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.92   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
60.3
myeloid white cell count
1
1
1
53.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
60.3
myeloid white cell count
1
53.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plexin B1
VGNC:2517
460344
Macaque
plexin B1
709802
Mouse
MGI:2154238
235611
Rat
RGD:1310564
316009
Dog
plexin B1
VGNC:44722
476636
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plexin B1
Macaque
plexin B1
Mouse
Rat
Dog
plexin B1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43157-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
Sema4D in semaphorin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
G alpha (12/13) signalling events
GPCR downstream signalling
Sema4D in semaphorin signaling
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (102)
1 – 10 of 102
SMPX
Tbio
Novelty: 0.05084864
p_int: 0.999185834
p_ni: 0.000813813
p_wrong: 3.54e-7
Score: 0.622
Data Source: BioPlex,STRINGDB
HBB
Tbio
Novelty: 0.00049683
p_int: 0.997697138
p_ni: 0.002302857
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
HBA1
Tclin
Novelty: 0.00094113
p_int: 0.874763597
p_ni: 0.124487931
p_wrong: 0.000748472
Data Source: BioPlex
SEMA4D
Tbio
Novelty: 0.0043592
Score: 0.997
Data Source: Reactome,STRINGDB
RND1
Tbio
Family: Enzyme
Novelty: 0.00834946
Score: 0.997
Data Source: Reactome,STRINGDB
ARHGEF12
Tbio
Novelty: 0.01365866
Score: 0.985
Data Source: Reactome,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.981
Data Source: Reactome,STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
Score: 0.98
Data Source: Reactome,STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.978
Data Source: Reactome,STRINGDB
ARHGEF11
Tbio
Novelty: 0.01942359
Score: 0.977
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  91.92

PubMed score by year
PubTator Score  254.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer