Protein Summary
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
- ENST00000296440
- ENSP00000296440
- ENSG00000164050
- ENST00000358536
- ENSP00000351338
- ENST00000449094
- ENSP00000395987
- ENST00000456774
- ENSP00000414199
- KIAA0407
- PLXN5
- SEP
- SEP
- PLXN5
- PLEXIN-B1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
tissue sample | 0.77 | ||
transcription factor | 0.76 | ||
tissue | 0.72 | ||
virus perturbation | 0.72 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.92 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 251 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.92 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 251 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
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1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 60.3 | |||||
myeloid white cell count | 1 | 1 | 1 | 53.6 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 60.3 | |||||
myeloid white cell count | 1 | 53.6 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | plexin B1 | VGNC:2517 | 460344 | |||||
Macaque | plexin B1 | 709802 | ||||||
Mouse | MGI:2154238 | 235611 | ||||||
Rat | RGD:1310564 | 316009 | ||||||
Dog | plexin B1 | VGNC:44722 | 476636 | |||||
Protein Structure (9 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (12)
Reactome (10)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | G alpha (12/13) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Sema4D in semaphorin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
G alpha (12/13) signalling events | ||||
GPCR downstream signalling | ||||
Sema4D in semaphorin signaling | ||||
Gene Ontology Terms (28)
Functions (6)
Components (4)
Processes (18)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (102)
1 – 10 of 102
SMPX
Novelty: 0.05084864
p_int: 0.999185834
p_ni: 0.000813813
p_wrong: 3.54e-7
Score: 0.622
Data Source: BioPlex,STRINGDB
HBB
Novelty: 0.00049683
p_int: 0.997697138
p_ni: 0.002302857
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
HBA1
Novelty: 0.00094113
p_int: 0.874763597
p_ni: 0.124487931
p_wrong: 0.000748472
Data Source: BioPlex
SEMA4D
Novelty: 0.0043592
Score: 0.997
Data Source: Reactome,STRINGDB
RND1
Family: Enzyme
Novelty: 0.00834946
Score: 0.997
Data Source: Reactome,STRINGDB
ARHGEF12
Novelty: 0.01365866
Score: 0.985
Data Source: Reactome,STRINGDB
RHOA
Family: Enzyme
Novelty: 0.00022204
Score: 0.981
Data Source: Reactome,STRINGDB
RRAS
Family: Enzyme
Novelty: 0.00786502
Score: 0.98
Data Source: Reactome,STRINGDB
ERBB2
Family: Kinase
Novelty: 0.00003761
Score: 0.978
Data Source: Reactome,STRINGDB
ARHGEF11
Novelty: 0.01942359
Score: 0.977
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 91.92
PubMed score by year
PubTator Score 254.77
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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