Tbio PLXNB1 Plexin-B1

Protein Summary

Description

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

Uniprot Accession IDs

• O43157
• A6H8Y2
• Q6NY20
• Q9UIV7
• Q9UJ92
• Q9UJ93

Gene Name

• PLXNB1

Ensembl ID

• ENST00000296440
• ENSP00000296440
• ENSG00000164050
• ENST00000358536
• ENSP00000351338
• ENST00000449094
• ENSP00000395987
• ENST00000456774
• ENSP00000414199

Symbol

• KIAA0407
• PLXN5
• SEP
• SEP
• PLXN5
• PLEXIN-B1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
tissue sample	0.77
transcription factor	0.76
tissue	0.72
virus perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.73   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 251   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.73   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0