Protein Summary
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
- ENST00000296440
- ENSP00000296440
- ENSG00000164050
- ENST00000358536
- ENSP00000351338
- ENST00000449094
- ENSP00000395987
- ENST00000456774
- ENSP00000414199
- KIAA0407
- PLXN5
- SEP
- SEP
- PLXN5
- PLEXIN-B1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
tissue sample | 0.77 | ||
transcription factor | 0.76 | ||
tissue | 0.72 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.37 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 251 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.37 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 251 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
SMPX
Novelty: 0.05084864
p_int: 0.999185834
p_ni: 0.000813813
p_wrong: 3.54e-7
Score: 0.622
Data Source: BioPlex,STRINGDB
HBB
Novelty: 0.00049683
p_int: 0.997697138
p_ni: 0.002302857
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
HBA1
Novelty: 0.00094113
p_int: 0.874763597
p_ni: 0.124487931
p_wrong: 0.000748472
Data Source: BioPlex
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (12)
Reactome (10)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | G alpha (12/13) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Sema4D in semaphorin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
G alpha (12/13) signalling events | ||||
GPCR downstream signalling | ||||
Sema4D in semaphorin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (6)
Components (4)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
macrophage inflammatory protein 1b measurement | 1 | 2 | 2 | 89.2 | |||||
self reported educational attainment | 2 | 3 | 3 | 84.1 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 81 | |||||
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 79.6 | |||||
mathematical ability | 3 | 1 | 3 | 69.8 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
macrophage inflammatory protein 1b measurement | 2 | 89.2 | |||||
self reported educational attainment | 3 | 84.1 | |||||
BMI-adjusted waist circumference | 2 | 81 | |||||
BMI-adjusted waist-hip ratio | 2 | 79.6 | |||||
mathematical ability | 3 | 69.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | plexin B1 | VGNC:2517 | 460344 | |||||
Macaque | plexin B1 | 709802 | ||||||
Mouse | MGI:2154238 | 235611 | ||||||
Rat | RGD:1310564 | 316009 | ||||||
Dog | plexin B1 | VGNC:44722 | 476636 | |||||
Publication Statistics
PubMed Score 92.37
PubMed score by year
PubTator Score 254.77
PubTator score by year
Related Publications
Text Mined References (67)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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