Protein Summary
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
- ENST00000296440
- ENSP00000296440
- ENSG00000164050
- ENST00000358536
- ENSP00000351338
- ENST00000449094
- ENSP00000395987
- ENST00000456774
- ENSP00000414199
- KIAA0407
- PLXN5
- SEP
- SEP
- PLXN5
- PLEXIN-B1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
tissue sample | 0.77 | ||
transcription factor | 0.76 | ||
tissue | 0.72 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.37 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 251 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.37 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 251 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
SMPX
Novelty: 0.05084864
p_int: 0.999185834
p_ni: 0.000813813
p_wrong: 3.54e-7
Score: 0.622
Data Source: BioPlex,STRINGDB
HBB
Novelty: 0.00049683
p_int: 0.997697138
p_ni: 0.002302857
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
HBA1
Novelty: 0.00094113
p_int: 0.874763597
p_ni: 0.124487931
p_wrong: 0.000748472
Data Source: BioPlex
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (12)
Reactome (10)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | G alpha (12/13) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Sema4D in semaphorin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
G alpha (12/13) signalling events | ||||
GPCR downstream signalling | ||||
Sema4D in semaphorin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (6)
Components (4)
Processes (18)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
macrophage inflammatory protein 1b measurement | 1 | 2 | 2 | 89.2 | |||||
self reported educational attainment | 2 | 3 | 3 | 84.1 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 81 | |||||
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 79.6 | |||||
mathematical ability | 3 | 1 | 3 | 69.8 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
macrophage inflammatory protein 1b measurement | 2 | 89.2 | |||||
self reported educational attainment | 3 | 84.1 | |||||
BMI-adjusted waist circumference | 2 | 81 | |||||
BMI-adjusted waist-hip ratio | 2 | 79.6 | |||||
mathematical ability | 3 | 69.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | plexin B1 | VGNC:2517 | 460344 | |||||
Macaque | plexin B1 | 709802 | ||||||
Mouse | MGI:2154238 | 235611 | ||||||
Rat | RGD:1310564 | 316009 | ||||||
Dog | plexin B1 | VGNC:44722 | 476636 | |||||
Publication Statistics
PubMed Score 92.37
PubMed score by year
PubTator Score 254.77
PubTator score by year
Related Publications
Text Mined References (67)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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