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Tbio
TTI1
TELO2-interacting protein 1 homolog

Protein Summary
Description
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373447
  • ENSP00000362546
  • ENSG00000101407
  • ENST00000373448
  • ENSP00000362547
  • ENST00000449821
  • ENSP00000407270

Symbol
  • KIAA0406
  • SMG10
  • smg-10
  • KIAA0406
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
interacting protein
0.85
histone modification site profile
0.74
transcription factor binding site profile
0.73
hub protein
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.94   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.94   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.999267484
p_ni:  0.000732516
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.999156804
p_ni:  0.000843082
p_wrong:  1.14e-7
Data Source:  BioPlex
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.99857768
p_ni:  0.001422319
p_wrong:  1e-9
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.992167123
p_ni:  0.007832877
Data Source:  BioPlex
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.992110789
p_ni:  0.007889211
Data Source:  BioPlex
TMEM51
Tdark
Novelty:  0.54147214
p_int:  0.978787708
p_ni:  0.021212291
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
CD70
Tbio
Novelty:  0.00420393
p_int:  0.937444451
p_ni:  0.062555549
Data Source:  BioPlex
CD274
Tclin
Novelty:  0.00013449
p_int:  0.914976318
p_ni:  0.085023682
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.90059106
p_ni:  0.09940894
Data Source:  BioPlex
CHRM3
Tclin
Family:  GPCR
Novelty:  0.00849776
p_int:  0.899105885
p_ni:  0.100894115
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TELO2 interacting protein 1
VGNC:6290
458235
Macaque
TELO2 interacting protein 1
699930
Mouse
MGI:1922675
75425
Rat
RGD:1562582
499935
Dog
TELO2 interacting protein 1
VGNC:47969
477225
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TELO2 interacting protein 1
Macaque
TELO2 interacting protein 1
Mouse
Rat
Dog
TELO2 interacting protein 1
Publication Statistics
PubMed Score 12.94
PubMed score by year
PubTator Score 6.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title