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Tbio
FLRT2
Leucine-rich repeat transmembrane protein FLRT2

Protein Summary
Description
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330753
  • ENSP00000332879
  • ENSG00000185070
  • ENST00000554746
  • ENSP00000451050

Symbol
  • KIAA0405
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
protein domain
0.85
transcription factor perturbation
0.8
small molecule perturbation
0.74
microRNA
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.68   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.68   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
2
1
2
45.8
hemoglobin measurement
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
2
45.8
hemoglobin measurement
1
8.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fibronectin leucine rich transmembrane protein 2
709329
Mouse
MGI:3603594
399558
Rat
RGD:1308574
299236
Dog
fibronectin leucine rich transmembrane protein 2
VGNC:40905
490820
Horse
fibronectin leucine rich transmembrane protein 2
VGNC:18065
100052762
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fibronectin leucine rich transmembrane protein 2
Mouse
Rat
Dog
fibronectin leucine rich transmembrane protein 2
Horse
fibronectin leucine rich transmembrane protein 2
Pathways (5)
Downstream signaling of activated FGFR1 (R-HSA-5654687)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downstream signaling of activated FGFR1
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Downstream signaling of activated FGFR1
Signal Transduction
Signaling by FGFR
Signaling by FGFR1
Signaling by Receptor Tyrosine Kinases
Protein-Protein Interactions (44)
1 – 10 of 44
FGF9
Tbio
Novelty: 0.003428
Score: 0.908
Data Source: STRINGDB
FGF10
Tbio
Novelty: 0.00217451
Score: 0.904
Data Source: STRINGDB
FGF2
Tchem
Novelty: 0.00007856
Score: 0.903
Data Source: STRINGDB
FGF1
Tchem
Novelty: 0.00055979
Score: 0.902
Data Source: STRINGDB
FGF23
Tclin
Novelty: 0.00047318
Score: 0.902
Data Source: Reactome,STRINGDB
FGF22
Tbio
Novelty: 0.0553003
Score: 0.901
Data Source: STRINGDB
FGF6
Tbio
Novelty: 0.021785
Score: 0.901
Data Source: STRINGDB
FGF20
Tbio
Novelty: 0.0145462
Score: 0.901
Data Source: STRINGDB
FGF3
Tbio
Novelty: 0.00474087
Score: 0.9
Data Source: STRINGDB
FGF4
Tbio
Novelty: 0.00180667
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.68

PubMed score by year
PubTator Score  8.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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