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Tbio
RNMT
mRNA cap guanine-N7 methyltransferase

Protein Summary
Description
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262173
  • ENSP00000262173
  • ENSG00000101654
  • ENST00000383314
  • ENSP00000372804
  • ENST00000543302
  • ENSP00000446426
  • ENST00000589866
  • ENSP00000466252
  • ENST00000592764
  • ENSP00000466111

Symbol
  • KIAA0398
  • MET
  • Met
  • CMT1
  • cm1p
  • hMet
  • CMT1c
  • hCMT1
  • RG7MT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
interacting protein
0.93
histone modification site profile
0.87
transcription factor binding site profile
0.84
microRNA
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.55   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.55   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
RAMAC
Tbio
Novelty:  0.62296468
p_int:  0.999806412
p_ni:  0.000193588
Score:  0.998
Data Source:  BioPlex,STRINGDB
KPNA6
Tbio
Novelty:  0.03516499
p_int:  0.99281409
p_ni:  0.00718591
Score:  0.338
Data Source:  BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int:  0.989586543
p_ni:  0.010413457
p_wrong:  1e-9
Data Source:  BioPlex
TRPC4AP
Tbio
Novelty:  0.02170224
p_int:  0.988950885
p_ni:  0.011049115
Score:  0.165
Data Source:  BioPlex,STRINGDB
KPNA1
Tbio
Novelty:  0.00863582
p_int:  0.945766018
p_ni:  0.054233982
Score:  0.518
Data Source:  BioPlex,STRINGDB
KPNA5
Tbio
Novelty:  0.0762372
p_int:  0.907711567
p_ni:  0.092288433
Score:  0.409
Data Source:  BioPlex,STRINGDB
RNGTT
Tbio
Novelty:  0.01433659
Score:  0.997
Data Source:  Reactome,STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.966
Data Source:  Reactome,STRINGDB
CMTR1
Tbio
Family:  Enzyme
Novelty:  0.09259694
Score:  0.958
Data Source:  STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
HIV Infection
HIV Life Cycle
Infectious disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
9
99
2
2
1
1
89.3
alkaline phosphatase measurement
2
2
1
5.7
60.8
C-reactive protein measurement
1
1
1
46.1
femoral neck bone mineral density
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
9
99
1
1
89.3
alkaline phosphatase measurement
1
5.7
60.8
C-reactive protein measurement
1
46.1
femoral neck bone mineral density
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA guanine-7 methyltransferase
VGNC:10006
455501
Macaque
RNA guanine-7 methyltransferase
100430132
Mouse
MGI:1915147
67897
Rat
RGD:1309242
291534
Dog
RNA guanine-7 methyltransferase
476200
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA guanine-7 methyltransferase
Macaque
RNA guanine-7 methyltransferase
Mouse
Rat
Dog
RNA guanine-7 methyltransferase
Publication Statistics
PubMed Score 98.55
PubMed score by year
PubTator Score 26.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title