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Tbio
DHX15
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15

Protein Summary
Description
Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336812
  • ENSP00000336741
  • ENSG00000109606

Symbol
  • DBP1
  • DDX15
  • DBP1
  • HRH2
  • DDX15
  • PRP43
  • PRPF43
  • PrPp43p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
molecular function
0.99
protein domain
0.97
kinase perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.63   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.63   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (563)
KNOP1
Tdark
Novelty:  0.5609503
p_int:  0.934812176
p_ni:  0.065187824
Data Source:  BioPlex
ZGPAT
Tbio
Family:  Epigenetic
Novelty:  0.16971298
p_int:  0.933717666
p_ni:  0.066282334
Score:  0.347
Data Source:  BioPlex,STRINGDB
MTREX
Tbio
Novelty:  0.01358024
Score:  0.999
Data Source:  STRINGDB
TFIP11
Tbio
Novelty:  0.01546496
Score:  0.999
Data Source:  STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
Score:  0.997
Data Source:  STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
Score:  0.996
Data Source:  STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.996
Data Source:  STRINGDB
DDX5
Tbio
Family:  Enzyme
Novelty:  0.00637984
Score:  0.995
Data Source:  STRINGDB
SNRNP200
Tchem
Family:  Enzyme
Novelty:  0.01339666
Score:  0.995
Data Source:  STRINGDB
SF3B1
Tbio
Novelty:  0.0128965
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
9.6
apolipoprotein A 1 measurement
1
1
1
8.6
high density lipoprotein cholesterol measurement
1
1
1
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
9.6
apolipoprotein A 1 measurement
1
8.6
high density lipoprotein cholesterol measurement
1
1.3
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 15
VGNC:6419
461142
Macaque
DEAH-box helicase 15
715852
Mouse
MGI:1099786
13204
Rat
RGD:1308072
289693
Dog
DEAH-box helicase 15
VGNC:39939
488856
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 15
Macaque
DEAH-box helicase 15
Mouse
Rat
Dog
DEAH-box helicase 15
Publication Statistics
PubMed Score 89.63
PubMed score by year
PubTator Score 42.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title