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Tchem
KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

Protein Classes
Protein Summary
Description
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262888
  • ENSP00000262888
  • ENSG00000104783
  • ENST00000648319
  • ENSP00000496939

Symbol
  • IK1
  • IKCA1
  • KCA4
  • SK4
  • IK
  • IK1
  • SK4
  • DHS2
  • KCA4
  • hSK4
  • IKCA1
  • hKCa4
  • KCa3.1
  • hIKCa1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
molecular function
0.91
kinase perturbation
0.88
small molecule perturbation
0.74
biological process
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 504.1   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 504.1   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 48
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (48)
1 – 10 of 48
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
94.1
apolipoprotein B measurement
1
2
2
92.4
low density lipoprotein cholesterol measurement
1
2
2
90.8
hemoglobin measurement
3
2
3
82.7
monocyte count
1
1
1
81.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
94.1
apolipoprotein B measurement
2
92.4
low density lipoprotein cholesterol measurement
2
90.8
hemoglobin measurement
3
82.7
monocyte count
1
81.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily N member 4
VGNC:7484
456098
Mouse
MGI:1277957
16534
Rat
RGD:621476
65206
Dog
potassium calcium-activated channel subfamily N member 4
VGNC:42287
484464
Cow
potassium calcium-activated channel subfamily N member 4
VGNC:30486
534591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily N member 4
Mouse
Rat
Dog
potassium calcium-activated channel subfamily N member 4
Cow
potassium calcium-activated channel subfamily N member 4
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15554-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Neuronal System
Potassium Channels
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (88)
1 – 10 of 88
KCNMA1
Tclin
Family:  IC
Novelty:  0.00088182
Score:  0.961
Data Source:  STRINGDB
KCNMB4
Tbio
Family:  IC
Novelty:  0.05362954
Score:  0.939
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.937
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.926
Data Source:  STRINGDB
KCNK5
Tchem
Family:  IC
Novelty:  0.00932619
Score:  0.905
Data Source:  STRINGDB
KCNE3
Tbio
Family:  IC
Novelty:  0.01541806
Score:  0.904
Data Source:  STRINGDB
KCNU1
Tbio
Family:  IC
Novelty:  0.02284336
Score:  0.898
Data Source:  STRINGDB
KCNMB1
Tbio
Family:  IC
Novelty:  0.00736653
Score:  0.884
Data Source:  STRINGDB
CALM2
Tclin
Novelty:  0.01876254
Score:  0.883
Data Source:  STRINGDB
PHPT1
Tbio
Family:  Enzyme
Novelty:  0.02128852
Score:  0.867
Data Source:  STRINGDB
Publication Statistics
PubMed Score  504.10

PubMed score by year
PubTator Score  307.22

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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