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Tbio
MEFV
Pyrin

Protein Classes
Protein Summary
Description
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubM ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219596
  • ENSP00000219596
  • ENSG00000103313
  • ENST00000536379
  • ENSP00000445079
  • ENST00000541159
  • ENSP00000438711

Symbol
  • MEF
  • TRIM20
  • FMF
  • MEF
  • TRIM20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cell type or tissue
0.85
cellular component
0.69
phenotype
0.68
disease
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1348.59   (req: < 5)
Gene RIFs: 278   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1348.59   (req: >= 5)
Gene RIFs: 278   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4.8
54.4
heel bone mineral density
1
1
1
30.2
mean corpuscular volume
1
1
1
10.6
gut microbiome measurement
1
1
0
5.5
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4.8
54.4
heel bone mineral density
1
30.2
mean corpuscular volume
1
10.6
gut microbiome measurement
0
5.5
0.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MEFV, pyrin innate immunity regulator
VGNC:14880
107968776
Macaque
MEFV, pyrin innate immunity regulator
701927
Mouse
MGI:1859396
54483
Rat
RGD:61889
58923
Dog
MEFV, pyrin innate immunity regulator
VGNC:43146
490041
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MEFV, pyrin innate immunity regulator
Macaque
MEFV, pyrin innate immunity regulator
Mouse
Rat
Dog
MEFV, pyrin innate immunity regulator
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15553-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome
The NLRP3 inflammasome
Name
Explore in Pharos
Explore in Source
Immune System
Inflammasomes
Innate Immune System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
The NLRP3 inflammasome
Gene Ontology Terms (22)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (107)
1 – 10 of 107
PSTPIP1
Tbio
Family:  Enzyme
Novelty:  0.0114281
Score:  0.996
Data Source:  Reactome,STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.967
Data Source:  STRINGDB
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.956
Data Source:  Reactome,STRINGDB
AIM2
Tbio
Novelty:  0.00360474
Score:  0.847
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.84
Data Source:  STRINGDB
NLRC4
Tbio
Novelty:  0.0032237
Score:  0.82
Data Source:  STRINGDB
NLRP1
Tbio
Novelty:  0.00441627
Score:  0.807
Data Source:  STRINGDB
IL18
Tbio
Novelty:  0.00022844
Score:  0.804
Data Source:  STRINGDB
NLRP2
Tbio
Novelty:  0.00787844
Score:  0.791
Data Source:  STRINGDB
NLRP7
Tbio
Novelty:  0.01301125
Score:  0.788
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1348.59

PubMed score by year
PubTator Score  1411

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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