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Tchem
FFAR2
Free fatty acid receptor 2

Protein Summary
Description
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246549
  • ENSP00000246549
  • ENSG00000126262
  • ENST00000599180
  • ENSP00000473159

Symbol
  • FFA2
  • GPCR43
  • GPR43
  • FFA2R
  • GPR43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.85
biological process
0.83
cell type or tissue
0.63
tissue sample
0.54
ligand (chemical)
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.13   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.13   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
76.3
red blood cell distribution width
2
2
2
42.4
monocyte percentage of leukocytes
1
1
1
30.2
neutrophil count
1
1
1
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
76.3
red blood cell distribution width
2
42.4
monocyte percentage of leukocytes
1
30.2
neutrophil count
1
13.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
free fatty acid receptor 2
VGNC:11096
455948
Macaque
free fatty acid receptor 2
709026
Mouse
MGI:2441731
233079
Rat
RGD:1359614
292794
Dog
free fatty acid receptor 2
VGNC:40831
484580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
free fatty acid receptor 2
Macaque
free fatty acid receptor 2
Mouse
Rat
Dog
free fatty acid receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15552-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Free fatty acid receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Free fatty acid receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (198)
1 – 10 of 198
FFAR4
Tchem
Family: GPCR
Novelty: 0.00439747
Score: 0.981
Data Source: STRINGDB
GPRC6A
Tchem
Family: GPCR
Novelty: 0.01625616
Score: 0.97
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.965
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.945
Data Source: STRINGDB
CASR
Tclin
Family: GPCR
Novelty: 0.00061316
Score: 0.944
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.935
Data Source: STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
Score: 0.932
Data Source: STRINGDB
CCKAR
Tclin
Family: GPCR
Novelty: 0.00152339
Score: 0.923
Data Source: STRINGDB
FFAR1
Tchem
Family: GPCR
Novelty: 0.00271782
Score: 0.92
Data Source: STRINGDB
GRK5
Tchem
Family: Kinase
Novelty: 0.01108012
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  326.13

PubMed score by year
PubTator Score  75.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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