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Tbio
CLDN3
Claudin-3

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395145
  • ENSP00000378577
  • ENSG00000165215

Symbol
  • C7orf1
  • CPETR2
  • RVP1
  • HRVP1
  • C7orf1
  • CPE-R2
  • CPETR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.88
disease
0.73
transcription factor binding site profile
0.63
histone modification site profile
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.52   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 521   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.52   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 521   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
7
7
98.1
mean platelet volume
3
2
3
82.9
IGF-1 measurement
1
2
2
79.8
serum gamma-glutamyl transferase measurement
1
1
1
66.8
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
98.1
mean platelet volume
3
82.9
IGF-1 measurement
2
79.8
serum gamma-glutamyl transferase measurement
1
66.8
1
33.1
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 3
VGNC:4309
742734
Macaque
claudin 3
716771
Mouse
MGI:1329044
12739
Rat
RGD:68425
65130
Dog
claudin 3
VGNC:39319
403648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 3
Macaque
claudin 3
Mouse
Rat
Dog
claudin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15551-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (50)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Protein-Protein Interactions (72)
1 – 10 of 72
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.979
Data Source:  STRINGDB
CLDN1
Tbio
Novelty:  0.00505039
Score:  0.947
Data Source:  STRINGDB
OCLN
Tbio
Novelty:  0.00047671
Score:  0.947
Data Source:  STRINGDB
CLDN5
Tbio
Novelty:  0.00174396
Score:  0.939
Data Source:  STRINGDB
CLDN7
Tbio
Novelty:  0.00722366
Score:  0.934
Data Source:  STRINGDB
CLDN4
Tbio
Novelty:  0.00227337
Score:  0.933
Data Source:  STRINGDB
CLDN16
Tbio
Novelty:  0.0092505
Score:  0.926
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.922
Data Source:  STRINGDB
CLDN11
Tbio
Novelty:  0.00275436
Score:  0.916
Data Source:  STRINGDB
CLDN2
Tbio
Novelty:  0.00299455
Score:  0.913
Data Source:  STRINGDB
Publication Statistics
PubMed Score  352.52

PubMed score by year
PubTator Score  170.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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