Tchem KDM6A Lysine-specific demethylase 6A

Protein Summary

Description

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• O15550
• Q52LL9
• Q5JVQ7

Gene Name

• KDM6A

Ensembl ID

• ENST00000377967
• ENSP00000367203
• ENSG00000147050

Symbol

• UTX
• UTX
• KABUK2
• bA386N14.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
protein domain	0.85
virus perturbation	0.83
transcription factor binding site profile	0.71
transcription factor	0.68

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Lysine-specific Demethylase 6a

DTO Classes

Protein / Epigenetic Regulator / Eraser / Lysine Demethylase / Jumonji Domain-containing / Lysine-specific Demethylase 6a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 552.8   (req: < 5)

Gene RIFs: 140   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 552.8   (req: >= 5)

Gene RIFs: 140   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0