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Tchem
P2RX6
P2X purinoceptor 6

Protein Summary
Description
Receptor for ATP that acts as a ligand-gated ion channel. The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401443
  • ENSP00000385309
  • ENSG00000099957
  • ENST00000413302
  • ENSP00000416193

Symbol
  • P2RXL1
  • P2X6
  • P2X6
  • P2XM
  • P2RXL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cellular component
0.75
histone modification site profile
0.71
cell type or tissue
0.55
disease perturbation
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.09   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.09   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2X 6
VGNC:8863
745626
Macaque
purinergic receptor P2X 6
695841
Mouse
MGI:1337113
18440
Rat
RGD:3243
25041
Dog
purinergic receptor P2X 6
VGNC:44211
486436
Species
Name
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2X 6
Macaque
purinergic receptor P2X 6
Mouse
Rat
Dog
purinergic receptor P2X 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15547-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Elevation of cytosolic Ca2+ levels (R-HSA-139853)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
Hemostasis
Reactome
Platelet calcium homeostasis
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Elevation of cytosolic Ca2+ levels
Hemostasis
Platelet calcium homeostasis
Platelet homeostasis
Gene Ontology Terms (27)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
BHF-UCL
Protein-Protein Interactions (24)
1 – 10 of 24
DNAJB5
Tbio
Novelty: 0.20703358
p_int: 0.999586442
p_ni: 0.000413557
p_wrong: 1e-9
Score: 0.866
Data Source: BioPlex,STRINGDB
BAG5
Tbio
Novelty: 0.0318404
p_int: 0.936324998
p_ni: 0.063675002
Score: 0.29
Data Source: BioPlex,STRINGDB
DNAJB4
Tbio
Novelty: 0.03467352
p_int: 0.758673599
p_ni: 0.2413264
p_wrong: 1e-9
Score: 0.816
Data Source: BioPlex,STRINGDB
P2RX2
Tchem
Family: IC
Novelty: 0.00241146
Score: 0.932
Data Source: STRINGDB
P2RX4
Tchem
Family: IC
Novelty: 0.00242958
Score: 0.928
Data Source: STRINGDB
P2RX5
Tchem
Family: IC
Novelty: 0.01591178
Score: 0.923
Data Source: STRINGDB
P2RX1
Tchem
Family: IC
Novelty: 0.00286826
Score: 0.922
Data Source: STRINGDB
P2RX7
Tchem
Family: IC
Novelty: 0.00090502
Score: 0.916
Data Source: STRINGDB
P2RX3
Tchem
Family: IC
Novelty: 0.00203167
Score: 0.911
Data Source: STRINGDB
P2RY4
Tchem
Family: GPCR
Novelty: 0.00903213
Score: 0.78
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.09

PubMed score by year
PubTator Score  23.91

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer