Tbio RNF113A E3 ubiquitin-protein ligase RNF113A

Protein Summary

Description

E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• O15541
• B2RBR7

Gene Name

• RNF113A

Ensembl ID

• ENST00000371442
• ENSP00000360497
• ENSG00000125352

Symbol

• RNF113
• ZNF183
• TTD5
• Cwc24
• RNF113
• ZNF183

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
ligand (protein) perturbation	0.83
histone modification site profile	0.8
cell type or tissue	0.63
tissue sample	0.62

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / E3 Ubiquitin-protein Ligase Rnf113a

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Rnf113a

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Ring Finger Protein 113a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.09   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.09   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0