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Tbio
FABP7
Fatty acid-binding protein, brain

Protein Summary
Description
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity). The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356535
  • ENSP00000348931
  • ENSG00000164434
  • ENST00000368444
  • ENSP00000357429

Symbol
  • BLBP
  • FABPB
  • MRG
  • MRG
  • BLBP
  • FABPB
  • B-FABP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
PubMedID
0.92
small molecule perturbation
0.61
biological term
0.59
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.88   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 549   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.88   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 549   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 7
VGNC:7176
472116
Mouse
MGI:101916
12140
Rat
RGD:69312
80841
Dog
fatty acid binding protein 7
VGNC:40563
476278
Horse
fatty acid binding protein 7
VGNC:17770
100067280
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 7
Mouse
Rat
Dog
fatty acid binding protein 7
Horse
fatty acid binding protein 7
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15540-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
NOTCH3 Intracellular Domain Regulates Transcription
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
NOTCH3 Intracellular Domain Regulates Transcription
Signal Transduction
Signaling by NOTCH
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (96)
1 – 10 of 96
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.951
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.938
Data Source: STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.935
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.912
Data Source: STRINGDB
LIPE
Tchem
Family: Enzyme
Novelty: 0.00169872
Score: 0.912
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.911
Data Source: STRINGDB
KAT2B
Tchem
Family: Epigenetic
Novelty: 0.00172126
Score: 0.904
Data Source: STRINGDB
KAT2A
Tbio
Family: Epigenetic
Novelty: 0.00238831
Score: 0.904
Data Source: STRINGDB
MAML3
Tbio
Novelty: 0.05574812
Score: 0.903
Data Source: STRINGDB
MAML1
Tbio
Novelty: 0.01302751
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  229.88

PubMed score by year
PubTator Score  98.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer