FABP7
Fatty acid-binding protein, brain
Protein Summary
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity). The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]
- ENST00000356535
- ENSP00000348931
- ENSG00000164434
- ENST00000368444
- ENSP00000357429
- BLBP
- FABPB
- MRG
- MRG
- BLBP
- FABPB
- B-FABP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
PubMedID | 0.92 | ||
small molecule perturbation | 0.61 | ||
biological term | 0.59 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 278.84 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 549 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 278.84 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 549 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0