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Tbio
RGS5
Regulator of G-protein signaling 5

Protein Summary
Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313961
  • ENSP00000319308
  • ENSG00000143248
  • ENST00000527988
  • ENSP00000432313
  • ENST00000530507
  • ENSP00000433001
  • ENST00000618415
  • ENSP00000480891

Symbol
  • MST092
  • MST106
  • MST129
  • MSTP032
  • MSTP092
  • MSTP106
  • MSTP129
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
small molecule perturbation
0.82
gene perturbation
0.81
histone modification site profile
0.81
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.02   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 347   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.02   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (31)
1 – 10 of 31
OMP
Tbio
Novelty: 0.0034375
p_int: 0.932312888
p_ni: 0.067687093
p_wrong: 1.9e-8
Data Source: BioPlex
CST8
Tbio
Novelty: 0.00274495
p_int: 0.891670195
p_ni: 0.016808902
p_wrong: 0.091520903
Data Source: BioPlex
GNAI3
Tbio
Novelty: 0.03936457
Score: 0.954
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.04542644
Score: 0.954
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.12575547
Score: 0.954
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.004945
Score: 0.93
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.00176666
Score: 0.716
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00156526
Score: 0.603
Data Source: STRINGDB
GNAO1
Tbio
Novelty: 0.0056926
Score: 0.575
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.01077999
Score: 0.561
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.02

PubMed score by year
PubTator Score  52.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer