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Tbio
PER1
Period circadian protein homolog 1

Protein Summary
Description
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317276
  • ENSP00000314420
  • ENSG00000179094
  • ENST00000354903
  • ENSP00000346979

Symbol
  • KIAA0482
  • PER
  • RIGUI
  • PER
  • hPER
  • RIGUI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.94
transcription factor
0.94
transcription factor binding site profile
0.91
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.94   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.94   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
86
high density lipoprotein cholesterol measurement
1
1
1
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
86
high density lipoprotein cholesterol measurement
1
27.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
period circadian regulator 1
VGNC:9508
455098
Macaque
period circadian regulator 1
721948
Mouse
MGI:1098283
18626
Rat
RGD:727863
287422
Dog
period circadian regulator 1
VGNC:44420
489488
Species
Name
OMA
EggNOG
Inparanoid
Chimp
period circadian regulator 1
Macaque
period circadian regulator 1
Mouse
Rat
Dog
period circadian regulator 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15534-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Circadian Clock
Gene Ontology Terms (34)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (87)
1 – 10 of 87
CRY1
Tchem
Novelty: 0.00116593
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CRY2
Tbio
Novelty: 0.00156961
p_int: 0.999984285
p_ni: 0.000015715
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999966156
p_ni: 0.000033844
Score: 0.185
Data Source: BioPlex,STRINGDB
CSNK1D
Tchem
Family: Kinase
Novelty: 0.00896935
p_int: 0.999964742
p_ni: 0.000035258
Score: 0.993
Data Source: BioPlex,STRINGDB
CSNK1E
Tchem
Family: Kinase
Novelty: 0.00891859
p_int: 0.999822687
p_ni: 0.000177311
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PER3
Tbio
Novelty: 0.00350199
p_int: 0.999780699
p_ni: 0.000219301
Score: 0.979
Data Source: BioPlex,STRINGDB
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
p_int: 0.998886763
p_ni: 0.001113237
Score: 0.194
Data Source: BioPlex,STRINGDB
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.998128159
p_ni: 0.001871841
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.997945091
p_ni: 0.002054909
Data Source: BioPlex
TXNIP
Tbio
Novelty: 0.00216952
p_int: 0.996316897
p_ni: 0.003683088
p_wrong: 1.6e-8
Score: 0.208
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  76.94

PubMed score by year
PubTator Score  1774.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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