Protein Summary
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000374572
- ENSP00000363700
- ENSG00000112493
- ENST00000383066
- ENSP00000372543
- ENSG00000206208
- ENST00000383197
- ENSP00000372684
- ENSG00000206281
- ENST00000383198
- ENSP00000372685
- ENST00000395114
- ENSP00000378546
- ENST00000417059
- ENSP00000402087
- ENSG00000236490
- ENST00000434618
- ENSP00000395701
- ENSG00000231925
- ENST00000456807
- ENSP00000407195
- NGS17
- TAPA
- TPN
- TAPA
- TPSN
- NGS17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.98 | ||
molecular function | 0.98 | ||
cellular component | 0.85 | ||
PubMedID | 0.85 | ||
kinase perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 455.07 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 190 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 455.07 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 190 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0