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Tbio
TAPBP
Tapasin

Protein Summary
Description
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374572
  • ENSP00000363700
  • ENSG00000112493
  • ENST00000383066
  • ENSP00000372543
  • ENSG00000206208
  • ENST00000383197
  • ENSP00000372684
  • ENSG00000206281
  • ENST00000383198
  • ENSP00000372685
  • ENST00000395114
  • ENSP00000378546
  • ENST00000417059
  • ENSP00000402087
  • ENSG00000236490
  • ENST00000434618
  • ENSP00000395701
  • ENSG00000231925
  • ENST00000456807
  • ENSP00000407195

Symbol
  • NGS17
  • TAPA
  • TPN
  • TAPA
  • TPSN
  • NGS17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
molecular function
0.98
cellular component
0.85
PubMedID
0.85
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 343.05   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 343.05   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
82.1
body mass index
1
1
1
82.1
body mass index
1
1
1
82.1
body mass index
1
1
1
82.1
body mass index
1
1
1
82.1
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
82.1
body mass index
1
82.1
body mass index
1
82.1
body mass index
1
82.1
body mass index
1
82.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TAP binding protein
718235
Mouse
MGI:1201689
21356
Rat
RGD:3819
25217
Dog
TAP binding protein
VGNC:47106
481740
Horse
TAP binding protein
VGNC:23872
100061515
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TAP binding protein
Mouse
Rat
Dog
TAP binding protein
Horse
TAP binding protein
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15533-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Gene Ontology Terms (25)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (140)
1 – 10 of 140
HLA-DQB1
Tbio
Novelty: 0.00197952
p_int: 0.999993769
p_ni: 0.000006177
p_wrong: 5.4e-8
Score: 0.24
Data Source: BioPlex,STRINGDB
HFE
Tbio
Novelty: 0.00042077
p_int: 0.999987165
p_ni: 0.000010476
p_wrong: 0.00000236
Score: 0.288
Data Source: BioPlex,STRINGDB
HTR2C
Tclin
Family: GPCR
Novelty: 0.00074287
p_int: 0.999957335
p_ni: 0.000040389
p_wrong: 0.000002276
Score: 0.189
Data Source: BioPlex,STRINGDB
CHRNB4
Tclin
Family: IC
Novelty: 0.01151716
p_int: 0.999501968
p_ni: 0.000222773
p_wrong: 0.000275259
Data Source: BioPlex
PDIA3
Tbio
Family: Enzyme
Novelty: 0.00285939
Score: 0.997
Data Source: STRINGDB
B2M
Tbio
Novelty: 0.00011248
Score: 0.994
Data Source: STRINGDB
TAP2
Tbio
Novelty: 0.0390555
Score: 0.991
Data Source: Reactome,STRINGDB
TAP1
Tbio
Novelty: 0.02264011
Score: 0.986
Data Source: Reactome,STRINGDB
CALR
Tbio
Novelty: 0.0004479
Score: 0.984
Data Source: Reactome,STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  343.05

PubMed score by year
PubTator Score  217.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer