Tchem OGG1 N-glycosylase/DNA lyase

Protein Summary

Description

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• O15527
• A8K1E3
• O00390
• O00670
• O00705
• O14876
• O95488
• P78554
• Q9BW42
• Q9UIK0
• Q9UIK1
• Q9UIK2
• Q9UL34
• Q9Y2C0
• Q9Y2C1
• Q9Y6C3
• Q9Y6C4

Gene Name

• OGG1

Ensembl ID

• ENST00000302003
• ENSP00000305584
• ENSG00000114026
• ENST00000302008
• ENSP00000305527
• ENST00000302036
• ENSP00000306561
• ENST00000339511
• ENSP00000345520
• ENST00000344629
• ENSP00000342851
• ENST00000349503
• ENSP00000303132
• ENST00000383826
• ENSP00000373337
• ENST00000449570
• ENSP00000403598

Symbol

• MMH
• MUTM
• OGH1
• HMMH
• MUTM
• OGH1
• HOGG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.95
biological process	0.91
molecular function	0.91
disease perturbation	0.87
histone modification site profile	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1581.97   (req: < 5)

Gene RIFs: 491   (req: <= 3)

Antibodies: 428   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1581.97   (req: >= 5)

Gene RIFs: 491   (req: > 3)

Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0