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Tbio
SOCS1
Suppressor of cytokine signaling 1

Protein Summary
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332029
  • ENSP00000329418
  • ENSG00000185338
  • ENST00000644787
  • ENSP00000496577

Symbol
  • SSI1
  • TIP3
  • JAB
  • CIS1
  • SSI1
  • TIP3
  • CISH1
  • SSI-1
  • TIP-3
  • SOCS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological term
0.98
hub protein
0.98
transcription factor binding site profile
0.91
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 884.85   (req: < 5)
Gene RIFs: 294   (req: <= 3)
Antibodies: 567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 884.85   (req: >= 5)
Gene RIFs: 294   (req: > 3)
Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
35.4
reticulocyte measurement
1
1
1
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
35.4
reticulocyte measurement
1
32.6
Pathways (125)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Gene Ontology Terms (29)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (499)
1 – 10 of 499
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.992
Data Source: Reactome,STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.991
Data Source: Reactome,STRINGDB
ELOB
Tbio
Novelty: 0.01315739
Score: 0.986
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.984
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.982
Data Source: Reactome,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.978
Data Source: Reactome,STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00164278
Score: 0.978
Data Source: STRINGDB
IRS1
Tbio
Novelty: 0.00048281
Score: 0.977
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00005852
Score: 0.976
Data Source: STRINGDB
STAT6
Tchem
Family: TF
Novelty: 0.00096732
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  884.85

PubMed score by year
PubTator Score  949.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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