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Tbio
SOCS1
Suppressor of cytokine signaling 1

Protein Summary
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332029
  • ENSP00000329418
  • ENSG00000185338
  • ENST00000644787
  • ENSP00000496577

Symbol
  • SSI1
  • TIP3
  • JAB
  • CIS1
  • SSI1
  • TIP3
  • CISH1
  • SSI-1
  • TIP-3
  • SOCS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological term
0.98
hub protein
0.98
transcription factor binding site profile
0.91
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 909.01   (req: < 5)
Gene RIFs: 294   (req: <= 3)
Antibodies: 567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 909.01   (req: >= 5)
Gene RIFs: 294   (req: > 3)
Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (499)
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.992
Data Source:  Reactome,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.991
Data Source:  Reactome,STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.986
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.984
Data Source:  STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.982
Data Source:  Reactome,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.978
Data Source:  Reactome,STRINGDB
JAK3
Tclin
Family:  Kinase
Novelty:  0.00164278
Score:  0.978
Data Source:  STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.977
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.976
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 5 of 5
INSR
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
JAK3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (125)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
88.2
reticulocyte count
2
2
2
86.6
reticulocyte measurement
2
2
2
85.8
mean corpuscular volume
1
1
1
83.2
2
2
0
1.1
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
88.2
reticulocyte count
2
86.6
reticulocyte measurement
2
85.8
mean corpuscular volume
1
83.2
0
1.1
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
suppressor of cytokine signaling 1
VGNC:13790
737070
Macaque
suppressor of cytokine signaling 1
711180
Mouse
MGI:1354910
12703
Rat
RGD:69272
252971
Dog
suppressor of cytokine signaling 1
VGNC:46648
490006
Species
Name
OMA
EggNOG
Inparanoid
Chimp
suppressor of cytokine signaling 1
Macaque
suppressor of cytokine signaling 1
Mouse
Rat
Dog
suppressor of cytokine signaling 1
Publication Statistics
PubMed Score 909.01
PubMed score by year
PubTator Score 949.24
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title