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Tbio
NKX2-8
Homeobox protein Nkx-2.8

Protein Summary
Description
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258829
  • ENSP00000258829
  • ENSG00000136327

Symbol
  • NKX-2.8
  • NKX2G
  • NKX2H
  • NKX2H
  • NKX2.8
  • Nkx2-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cell type or tissue
0.68
biological process
0.67
PubMedID
0.66
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.2   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.2   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
HELZ
Tbio
Family:  Enzyme
Novelty:  0.08786982
Score:  0.8
Data Source:  STRINGDB
PAX9
Tbio
Family:  TF
Novelty:  0.00581813
Score:  0.785
Data Source:  STRINGDB
SMYD3
Tchem
Family:  Epigenetic
Novelty:  0.01040802
Score:  0.761
Data Source:  STRINGDB
PITX1
Tbio
Family:  TF
Novelty:  0.00499796
Score:  0.582
Data Source:  STRINGDB
VANGL1
Tbio
Novelty:  0.00968008
Score:  0.577
Data Source:  STRINGDB
OTX2
Tbio
Family:  TF
Novelty:  0.0024536
Score:  0.545
Data Source:  STRINGDB
ZBBX
Tdark
Novelty:  1.66474399
Score:  0.529
Data Source:  STRINGDB
FZD6
Tbio
Family:  GPCR
Novelty:  0.01425136
Score:  0.529
Data Source:  STRINGDB
OTX1
Tbio
Family:  TF
Novelty:  0.01074164
Score:  0.516
Data Source:  STRINGDB
DOK2
Tbio
Novelty:  0.02651438
Score:  0.485
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
0
1.1
58.4
intelligence
3
4
1
5.7
55.8
1
1
0
1.1
54.4
age at menarche
1
1
1
50.6
BMI-adjusted hip circumference
1
2
2
42.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
58.4
intelligence
1
5.7
55.8
0
1.1
54.4
age at menarche
1
50.6
BMI-adjusted hip circumference
2
42.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NK2 homeobox 8
VGNC:3363
467600
Mouse
MGI:1270158
18094
Rat
RGD:1310629
299061
Dog
NK2 homeobox 8
VGNC:43835
609776
Cow
NK2 homeobox 8
VGNC:32104
539075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NK2 homeobox 8
Mouse
Rat
Dog
NK2 homeobox 8
Cow
NK2 homeobox 8
Publication Statistics
PubMed Score 14.20
PubMed score by year
PubTator Score 10.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title